1. Cell Cycle/DNA Damage
  2. Telomerase


Telomerase is a ribonucleoprotein that is an enzyme that adds DNA sequence repeats ("TTAGGG" in all vertebrates) to the 3' end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. This region of repeated nucleotide called telomeres contains noncoding DNA and hinders the loss of important DNA from chromosome ends. As a result, every time the chromosome is copied, only 100–200 nucleotides are lost, which causes no damage to the organism's DNA. Telomerase is a reverse transcriptase that carries its own RNA molecule, which is used as a template when it elongates telomeres, which are shortened after each replication cycle. Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA and a protein reverse transcriptase subunit. By reverse transcription, the telomerase RNP maintains telomere length stability in almost all cancer cells.

Telomerase Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-13653
    (-)-Epigallocatechin Gallate Inhibitor 99.60%
    (-)-Epigallocatechin Gallate is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase, and blocks the activation of EGF receptors and HER-2 receptors.
  • HY-17353
    BIBR 1532 Inhibitor 99.55%
    BIBR 1532 is a potent, selective and non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay.
  • HY-U00268
    Telomerase-IN-1 Inhibitor
    Telomerase-IN-1 is a Telomerase inhibitor with an IC50 of 0.19 μM.