1. Cell Cycle/DNA Damage
  2. Topoisomerase

Topoisomerase

Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. Topoisomerases are isomerase enzymes that act on the topology of DNA. Type I topoisomerase cuts one strand of a DNA double helix, relaxation occurs, and then the cut strand is reannealed. Type I topoisomerases are subdivided into two subclasses: type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases, and type IB topoisomerases, which utilize a controlled rotary mechanism. Type II topoisomerase cuts both strands of one DNA double helix, pass another unbroken DNA helix through it, and then reanneal the cut strands. This class is also split into two subclasses: type IIA and type IIB topoisomerases, which possess similar structure and mechanisms.

Topoisomerase Related Products (57):

Cat. No. Product Name Effect Purity
  • HY-15142
    Doxorubicin hydrochloride Inhibitor 99.47%
    Doxorubicin hydrochloride is a Topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells.
  • HY-13629
    Etoposide Inhibitor 99.84%
    Etoposide is a topoisomerase II inhibitor, inhibiting DNA synthesis.
  • HY-16261
    INNO-206 Inhibitor
    INNO-206 is a prodrug of the anticancer agent doxorubicin, which is released from albumin under acidic conditions.
  • HY-16560
    Campathecin Inhibitor 98.26%
    Campathecin is a potent DNA enzyme topoisomerase I inhibitor, with an IC50 of 679 nM.
  • HY-13624A
    Epirubicin hydrochloride Inhibitor 98.15%
    Epirubicin (hydrochloride) is a semisynthetic L-arabino derivative of doxorubicin, and an antineoplastic agent by inhibiting Topoisomerase.
  • HY-18351
    Indotecan Inhibitor
    Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively.
  • HY-14812
    BNP 1350 Inhibitor
    BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity.
  • HY-13631D
    Dxd Inhibitor
    Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
  • HY-16562
    Irinotecan Inhibitor 98.78%
    Irinotecan is a water soluble topoisomerase I inhibitor with antitumor activity.
  • HY-13704
    SN-38 Inhibitor 99.46%
    SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan.
  • HY-13768A
    Topotecan Hydrochloride Inhibitor 99.20%
    Topotecan hydrochloride is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95±0.24 μM of GSCs-U87.
  • HY-13062
    Daunorubicin Hydrochloride Inhibitor 99.64%
    Daunorubicin hydrochloride is a topoisomerase II inhibitor.
  • HY-16562A
    Irinotecan hydrochloride Inhibitor 99.75%
    Irinotecan hydrochloride is a water soluble topoisomerase I inhibitor with antitumor activity.
  • HY-13631A
    Exatecan Mesylate Inhibitor 98.09%
    Exatecan Mesylate is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
  • HY-13061
    Daun02 Inhibitor 98.56%
    Daun02 is converted by β-galactosidase to Daunorubicin, which is a topoisomerase inhibitor.
  • HY-17381
    Idarubicin hydrochloride Inhibitor 99.62%
    Idarubicin hydrochloride is an anthracycline antibiotic in the treatment of leukaemia and a DNA topoisomerase II inhibitor.
  • HY-13555
    β-Lapachone Inhibitor 99.72%
    β-Lapachone is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
  • HY-13502
    Mitoxantrone Inhibitor >98.0%
    Mitoxantrone is a topoisomerase II inhibitor; also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM.
  • HY-16568
    Irinotecan hydrochloride trihydrate Inhibitor 99.59%
    Irinotecan hydrochloride trihydrate is a water soluble topoisomerase I inhibitor with antitumor activity.
  • HY-13761
    Teniposide Inhibitor 99.84%
    Teniposide is a podophyllotoxin derivative, acts as a topoisomerase II inhibitor, and used as a chemotherapeutic agent.