1. Cell Cycle/DNA Damage
  2. Topoisomerase

Topoisomerase

Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. Topoisomerases are isomerase enzymes that act on the topology of DNA. Type I topoisomerase cuts one strand of a DNA double helix, relaxation occurs, and then the cut strand is reannealed. Type I topoisomerases are subdivided into two subclasses: type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases, and type IB topoisomerases, which utilize a controlled rotary mechanism. Type II topoisomerase cuts both strands of one DNA double helix, pass another unbroken DNA helix through it, and then reanneal the cut strands. This class is also split into two subclasses: type IIA and type IIB topoisomerases, which possess similar structure and mechanisms.

Topoisomerase Related Products (57):

Cat. No. Product Name Effect Purity
  • HY-15142
    Doxorubicin hydrochloride Inhibitor
    Doxorubicin hydrochloride is a Topoisomerase II (Top2) catalytic inhibitor, also is a broad spectrum antibiotic used in the treatment of cancers, with IC50 of 374 nM for Hela cells.
  • HY-13629
    Etoposide Inhibitor
    Etoposide is a topoisomerase II inhibitor, inhibiting DNA synthesis.
  • HY-16261
    INNO-206 Inhibitor
    INNO-206 is a prodrug of the anticancer agent doxorubicin, which is released from albumin under acidic conditions.
  • HY-16560
    Campathecin Inhibitor
    Campathecin is a potent DNA enzyme topoisomerase I inhibitor, with an IC50 of 679 nM.
  • HY-13704
    SN-38 Inhibitor
    SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan.
  • HY-14812
    BNP 1350 Inhibitor
    BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity.
  • HY-13631D
    Dxd Inhibitor
    Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
  • HY-N0275
    (±)-10-Hydroxycamptothecin Inhibitor
    (±)-10-Hydroxycamptothecin, an indole alkaloid isolated from Camptotheca acuminate, inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.
  • HY-13624A
    Epirubicin hydrochloride Inhibitor
    Epirubicin (hydrochloride) is a semisynthetic L-arabino derivative of doxorubicin, and an antineoplastic agent by inhibiting Topoisomerase.
  • HY-16562
    Irinotecan Inhibitor
    Irinotecan is a water soluble topoisomerase I inhibitor with antitumor activity.
  • HY-13768A
    Topotecan Hydrochloride Inhibitor
    Topotecan hydrochloride is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95±0.24 μM of GSCs-U87.
  • HY-13062
    Daunorubicin Hydrochloride Inhibitor
    Daunorubicin hydrochloride is a topoisomerase II inhibitor.
  • HY-13631A
    Exatecan Mesylate Inhibitor
    Exatecan Mesylate is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
  • HY-16562A
    Irinotecan hydrochloride Inhibitor
    Irinotecan hydrochloride is a water soluble topoisomerase I inhibitor with antitumor activity.
  • HY-13061
    Daun02 Inhibitor
    Daun02 is converted by β-galactosidase to Daunorubicin, which is a topoisomerase inhibitor.
  • HY-17381
    Idarubicin hydrochloride Inhibitor
    Idarubicin hydrochloride is an anthracycline antibiotic in the treatment of leukaemia and a DNA topoisomerase II inhibitor.
  • HY-16568
    Irinotecan hydrochloride trihydrate Inhibitor
    Irinotecan hydrochloride trihydrate is a water soluble topoisomerase I inhibitor with antitumor activity.
  • HY-13555
    β-Lapachone Inhibitor
    β-Lapachone is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
  • HY-13761
    Teniposide Inhibitor
    Teniposide is a podophyllotoxin derivative, acts as a topoisomerase II inhibitor, and used as a chemotherapeutic agent.
  • HY-10529
    Betulinic acid Inhibitor
    Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties.