1. Metabolic Enzyme/Protease
  2. Tryptophan Hydroxylase

Tryptophan Hydroxylase

Thrombin is a serine protease that in humans is encoded by the F2 gene. Thrombin is an intriguing coagulation protease demonstrating an array of effects on endothelial cells, vascular smooth muscle cells (VSMC), monocytes, and platelets, all of which are involved in the pathophysiology of atherosclerosis. There is mounting evidence that thrombin acts as a powerful modulator of many processes like regulation of vascular tone, permeability, migration and proliferation of VSMC, recruitment of monocytes into the atherosclerotic lesions, induction of diverse pro-inflammatory markers, and all of these are related to the progression of cardiovascular disease. Recent studies in transgenic mice models indicate that the deletion of the natural thrombin inhibitor heparin cofactor II promotes an accelerated atherogenic state. The combined evidence points to thrombin as a pivotal contributor to vascular pathophysiology.

Tryptophan Hydroxylase Related Products (6):

Cat. No. Product Name Effect Purity
  • HY-13055B
    Telotristat Inhibitor
    Telotristat (LP-778902) is a potent tryptophan hydroxylase inhibitor with an in vivo IC50 of 0.028 μM.
  • HY-B1368
    4-Chloro-DL-phenylalanine Inhibitor 99.41%
    4-Chloro-DL-phenylalanine is a pharmaceutical intermediate.
  • HY-13055
    LX1606 Hippurate Inhibitor 99.87%
    LX1606 Hippurate is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
  • HY-13041
    LX-1031 Inhibitor 98.71%
    LX-1031 is a potent, orally available tryptophan 5-hydroxylase (TPH) inhibitor that reduces serotonin (5-HT) synthesis peripherally.
  • HY-13055A
    LX1606 Inhibitor
    LX1606 is a novel, orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
  • HY-15849
    LP-533401 Inhibitor >98.0%
    LP-533401 is a Tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.