1. Membrane Transporter/Ion Channel
  2. Aquaporin


Aquaporins (AQPs) are integral membrane proteins that facilitate the transport of water across biological membranes along an osmotic gradient. There have been 13 AQP isoforms (AQP0-AQP12) identified in humans and rodents to date. AQP0-2, 4-6 and 8 are generally considered to be exclusively water channels, whereas AQP3, 7, 9 and 10 are referred to as aquaglyceroporins, as they are also permeated by glycerol. AQPs usually adopt a tetramer conformation within the cell membrane, with each monomer consisting of a single aqueous pore that is permeable to water. The movement of water and solutes through AQP channels is a passive process that is dependent on the concentration of the transported molecule.

Aquaporin Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-115460
    AER-271 98.00%
    AER-271, a phosphonate proagent derivative of AER-270, is an aquaporin-4 (AQP4) inhibitor for the research of acute ischemic stroke[1].
  • HY-126073
    DFP00173 99.59%
    DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ∼0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9[1].
  • HY-110200
    TC AQP1 1 Inhibitor
    TC AQP1 1 (m-Phenylenediacrylic acid) is a potent AQP1 inhibitor. TC AQP1 1 inhibits AQP1-mediated water flux in oocytes, with an IC50 of 8 μM[1].
  • HY-126074
    Z433927330 98.01%
    Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC50s of ~0.2 µM, ~0.7 µM and ~1.1 µM for mAQP7, mAQP3 and mAQP9, respectively[1].
  • HY-N2057
    Steviol 99.43%
    Steviol is a major metabolite of the sweetening compound stevioside. Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation[1].