2. Membrane Transporter/Ion Channel
  3. Calmodulin

Calmodulin

Calmodulin is the highly conserved, calcium-sensitive protein, that acts as the calcium ion sensor in cells, Ca2+-dependently binds to target proteins, and converts Ca2+ concentrations into cellular signals. Calmodulin has four different Ca2+ binding sites named EF-hand for the sensing of Ca2+ signaling with different amplitude, duration, and location. Calmodulin dysfunction could lead to myocardial contractile problems, neuronal damage, or tumor angiogenesis dysregulation, which may cause cardiovascular diseases, neurological diseases, or cancer[1][2][3].

Calmodulin Related Products (45):

Cat. No. Product Name Effect Purity
  • HY-P1076A
    CALP2 TFA Antagonist 99.79%
    CALP2 TFA is a calmodulin (CaM) antagonist (Kd of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages[1][2][3][4].
  • HY-D0987
    Stains-All 99.91%
    Stains-All, a cationic carbocyanine dye, is a convenient probe to study the structural features of the individual calcium-binding sites of calmodulin (CaM) and related calcium-binding proteins (CaBP)[1][2].
  • HY-P1077A
    CALP1 TFA Agonist 99.86%
    CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity[1][2][3][4].
  • HY-100912
    W-7 hydrochloride Antagonist 99.96%
    W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively[1][2]. W-7 hydrochloride induces apoptosis and has antitumor activity[3].
  • HY-103319
    Calmidazolium chloride Antagonist
    Calmidazolium chloride (R 24571) is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively[1]. Also in anti-cancer research[2]. Calmidazolium binds to calmodulin with a Kd of 3 nM.
  • HY-168905
    SGC-CAMKK2-1 Inhibitor
    SGC-CAMKK2-1 is the selective, inhibitor for calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC50 of 30 nM. SGC-CAMKK2-1 inhibits AMPK phosphorylation in cell C4-2 with an IC50 of 1.6 µM[1].
  • HY-124176
    L-6355 Antagonist
    L-6355 is an Amiodarone (HY-14187) related compound, which inhibits Ca2+/calmodulin activated cyclic nucleotide phosphodiesterase with an IC50 value of 0.65 μM. L-6355 is promising for research of antiarrhythmic and antianginal agent[1].
  • HY-107661R
    Arundic Acid (Standard) Inhibitor
    Propiverine (hydrochloride) (Standard) is the analytical standard of Propiverine (hydrochloride). This product is intended for research and analytical applications. Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence[1][2].
  • HY-100911
    W-5 hydrochloride Antagonist 99.93%
    W-5 hydrochloride is a calmodulin antagonist. W-5 hydrochloride inhibits phosphodiesterase activation with an IC50 value of 240 µM. W-5 hydrochloride can be used as a negative control for W-7 (HY-100912)[1][2].
  • HY-N10772
    Albanin A Inhibitor
    Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca2+/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity[1].
  • HY-100914
    A-7 hydrochloride Antagonist 99.09%
    A-7 hydrochloride (Ophobolin A) is a calmodulin antagonist and can be used for the research of cancer[1].
  • HY-120997
    E6 Berbamine Antagonist
    E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activity of calmodulin (CaM)-dependent myosin light chain kinase (MLCK), with a Ki of 0.95 μM[1]. E6 Berbamine also shows anti-leukemia activities, with an IC50 of 2.13 μM in K562 cells[2].
  • HY-100263
    Metofenazate Inhibitor
    Metofenazate is a selective calmodulin inhibitor.
  • HY-P2473
    Neurogranin (48-76), human Modulator
    Neurogranin (48-76), human is a dominant endogenous peptide in Alzheimer's disease (AD) brain tissue. Neurogranin (48-76) is a potential biomarker for synaptic function in AD[1].
  • HY-125412
    Fasciculic acid B Antagonist
    Fasciculic acid B is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity[1][2].
  • HY-133782
    Fluphenazine-N-2-chloroethane hydrochloride Antagonist
    Fluphenazine-N-2-chloroethane (SKF-7171A) hydrochloride is a potent irreversible calmodulin antagonist[1][2].
  • HY-105118
    Zaldaride Inhibitor
    Zaldaride (CGS-9343B free base) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM[1][2]. Zaldaride prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR[3].
  • HY-N7733
    Fasciculic acid A Antagonist
    Fasciculic acid A is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity[1].
  • HY-P2471
    Neurogranin (48-76), mouse Inhibitor
    Neurogranin (48-76), mouse is a peptide corresponding to residues 48-76 of Neurogranin. Neurogranin, a calmodulin-binding protein, is exclusively expressed in the post-synapse, and mediates NMDAR driven synaptic plasticity by regulating the calcium-calmodulin (Ca2+-CaM) pathway[1].
  • HY-100913
    W-7 isomer hydrochloride Antagonist 99.65%
    W-7 isomer hydrochloride is an isomer of W-7 hydrochloride (HY-100912). W-7 hydrochloride is a selective calmodulin antagonist[1].