1. Membrane Transporter/Ion Channel
  2. Calmodulin

Calmodulin

Calmodulin (CaM), the member of EF-hand proteins superfamily, is a highly conserved eukaryotic Ca2+ sensor protein. Upon cellular stimulation, different mechanisms lead to transient intracellular increases in Ca2+ concentrations that initiate different protein activities. Most proteins are devoid of Ca2+ binding sites, requiring a mediator to respond to this cation. The ability to transmit conformational changes to a large and diverse array of proteins in response to Ca2+ oscillations, coordinating the activity of hundreds of proteins, makes calmodulin the most important Ca2+ signal transducer in eukaryotic cells. When Ca2+ binds to calmodulin it forms the Ca2+/calmodulin complex which then interacts with other proteins in the cell. These proteins are enzymes and effector proteins involved in a variety of cellular and physiological processes. The Ca2+/calmodulin complex can also regulate processes directly.

Calmodulin Related Products (26):

Cat. No. Product Name Effect Purity
  • HY-D0987
    Stains-All 99.91%
    Stains-All, a cationic carbocyanine dye, is a convenient probe to study the structural features of the individual calcium-binding sites of calmodulin (CaM) and related calcium-binding proteins (CaBP)[1][2].
  • HY-P1077A
    CALP1 TFA Agonist 98.30%
    CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity[1][2][3][4].
  • HY-100912
    W-7 hydrochloride Antagonist 99.65%
    W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 µM, respectively[1][2]. W-7 hydrochloride induces apoptosis and has antitumor activity[3].
  • HY-N7503
    Psoralenoside Inhibitor 99.84%
    Psoralenoside is a benzofuran glycoside from Psoralea corylifolia[1]. Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol)[2]. Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity[3].
  • HY-103319
    Calmidazolium chloride Antagonist
    Calmidazolium chloride (R 24571) is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively[1]. Also in anti-cancer research[2]. Calmidazolium binds to calmodulin with a Kd of 3 nM.
  • HY-133782
    Fluphenazine-N-2-chloroethane hydrochloride Antagonist
    Fluphenazine-N-2-chloroethane (SKF-7171A) hydrochloride is a potent irreversible calmodulin antagonist[1][2].
  • HY-106745
    Elziverine Antagonist
    Elziverine (Ro 22-4839) is a brain circulation improvement agent with vasospasm antispasmodic effects. Elziverine is a calmodulin antagonist. Elziverine inhibits erythrocyte cell membrane rupture, platelet aggregation and lipid peroxidation[1].
  • HY-106645
    Cloxacepride Antagonist
    Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity[1][2].
  • HY-P1076A
    CALP2 TFA Antagonist 98.48%
    CALP2 TFA is a calmodulin (CaM) antagonist (Kd of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages[1][2][3][4].
  • HY-N10772
    Albanin A Inhibitor
    Albanin A, a flavonoid, suppresses glutamate release by decreasing Ca2+/calmodulin/adenylate Cyclase 1 (AC1) activation in synaptosomes and exerts neuroprotective effect in vivo. Albanin A has anti-inflflammatory activity[1].
  • HY-100914
    A-7 hydrochloride Antagonist 99.09%
    A-7 hydrochloride (Ophobolin A) is a calmodulin antagonist and can be used for the research of cancer[1].
  • HY-100263
    Metofenazate Inhibitor
    Metofenazate is a selective calmodulin inhibitor.
  • HY-125412
    Fasciculic acid B Antagonist
    Fasciculic acid B is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity[1][2].
  • HY-N7733
    Fasciculic acid A Antagonist
    Fasciculic acid A is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity[1].
  • HY-P2471
    Neurogranin (48-76), mouse Inhibitor
    Neurogranin (48-76), mouse is a peptide corresponding to residues 48-76 of Neurogranin. Neurogranin, a calmodulin-binding protein, is exclusively expressed in the post-synapse, and mediates NMDAR driven synaptic plasticity by regulating the calcium-calmodulin (Ca2+-CaM) pathway[1].
  • HY-100913
    W-7 isomer hydrochloride Antagonist 99.50%
    W-7 isomer hydrochloride is an isomer of W-7 hydrochloride (HY-100912). W-7 hydrochloride is a selective calmodulin antagonist[1].
  • HY-P1076
    CALP2 Antagonist
    CALP2 is a calmodulin (CaM) antagonist ( (Kd of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages[1][2][3][4].
  • HY-N10198
    Acremonidin A Inhibitor
    Acremonidin A is a potent calmodulin (CaM) inhibitor found in Purpureocillium lilacinum. Acremonidin A binds to the human calmodulin (hCaM) biosensor hCaM M124C-mBBr, with Kd of 19.40 nM[1].
  • HY-P1805
    Calmodulin Binding Peptide 1 Inhibitor
    Calmodulin Binding Peptide 1 is a high affinity (pM) CaM-binding peptide derived from smooth muscle myosin light-chain kinase (MLCK peptide), which strongly inhibits IP3-induced Ca2+ release [1].
  • HY-115745
    Calmodulin antagonist-1 Antagonist
    Calmodulin antagonist-1 (A-5) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50=66 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50=560 μM) in a competitive fashion with respect to cyclic GMP[1].