1. GPCR/G Protein
  2. GPR171


GPR171 is a G protein-coupled receptor (GPCR) with close homology to the P2Y receptors. GPR171 is expressed within the periaqueductal gray. BigLEN, a 16-amino acid neuropeptide derived from a neuroendocrine secretory pathway protein proSAAS, has been identified as the endogenous ligand for GPR171. GPR171 is reported to regulate mu opioid receptor signaling, antinociception, feeding and anxiety behaviors. On the other hand, GPR171 is a well-accepted T-cell signature gene in cancer database analysis, though its potential immune function is untested. Based on early published databases, GPR171 expression tends to be upregulated in tumor-infiltrating lymphocytes (TILs) and its expression in melanoma patients is significantly increased in response to immunotherapies. All these imply a possible role of GPR171 in T-cell immunity.

GPR171 Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-112620
    MS21570 99.93%
    MS21570 is a selective GPR171 antagonist, with an IC50 of 220 nM.
  • HY-P2155A
    BigLEN(rat) TFA
    BigLEN(rat) is a potent GPR171 agonist with an EC50 of 1.6 nM[1].
  • HY-P2155
    BigLEN(rat) 98.98%
    BigLEN(rat) is a potent GPR171 agonist with an EC50 of 1.6 nM[1].
  • HY-P2210
    BigLEN(mouse) 99.90%
    BigLEN(mouse) is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a Kd of ∼0.5 nM. BigLEN(mouse) can be used to regulate responses associated with food intake and metabolism[1][2].