1. GPCR/G Protein
  2. mGluR

mGluR

mGluR (metabotropic glutamate receptor) is a type of glutamate receptor that are active through an indirect metabotropic process. They are members of thegroup C family of G-protein-coupled receptors, or GPCRs. Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatoryneurotransmitter. The mGluRs perform a variety of functions in the central and peripheral nervous systems: mGluRs are involved in learning, memory, anxiety, and the perception of pain. mGluRs are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and the cerebral cortex, as well as other parts of the brain and in peripheral tissues. Eight different types of mGluRs, labeled mGluR1 to mGluR8, are divided into groups I, II, and III. Receptor types are grouped based on receptor structure and physiological activity.

mGluR Related Products (45):

Cat. No. Product Name Effect Purity
  • HY-15445
    CTEP Antagonist
    CTEP is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors.
  • HY-18941
    LY354740 Agonist
    LY354740 is a highly potent, efficacious and selective group II (mGlu2/3) receptor agonist, used for treatment of anxiety and stress-related disorders.
  • HY-15257
    Mavoglurant Antagonist
    Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist, has an IC50 of 30 nM in a functional assay with human mGluR5.
  • HY-50906
    LY404039 Inhibitor
    LY404039 is an inhibitor for mGluR1(Ki=149 nM) and mGluR2(Ki= 92 nM), which can also inhibit dopamine receptor.
  • HY-14609
    MPEP Hydrochloride Antagonist
    MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM.
  • HY-107517
    UBP 1112 Antagonist
    UBP 1112 is a selective group III mGluR antagonist, with a Kd of 5.1 μM, 96-fold affinity for group III over group II mGlu receptor (Kd, 488 μM), and shows no significant activity at group I mGlu receptor or iGlu receptor.
  • HY-107457
    AZD-8529 Agonist
    AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
  • HY-N0390
    L-Glutamine Agonist
    L-Glutamine is a non-essential amino acid present abundantly throughout the body and is involved in gastrointestinal disorders.
  • HY-18654
    ADX88178 Agonist
    ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.
  • HY-14608A
    L-Glutamic acid monosodium salt Activator
    L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.
  • HY-15446
    RG7090 Inhibitor
    RG7090 (Basimglurant, RO4917523) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM.
  • HY-70059
    LY341495 Antagonist
    LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively.
  • HY-101845
    FITM Inhibitor
    FITM is a negative allosteric modulator of mGlu1 receptor with a Ki of 2.5 nM.
  • HY-15748
    JNJ-40411813 Agonist
    JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.
  • HY-B0122
    Topiramate Antagonist
    Topiramate is an anticonvulsant that antagonizes GluR5 receptors and acts as a positive allosteric modulator of GABA receptor-mediated currents.
  • HY-14859
    Dipraglurant Antagonist
    Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM.
  • HY-100407
    JNJ16259685 Antagonist
    JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.
  • HY-13206
    MTEP hydrochloride Antagonist
    MTEP Hcl is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively.
  • HY-100371
    (RS)-MCPG Antagonist
    (RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor antagonist.
  • HY-100406
    (S)-MCPG Antagonist
    (S)-MCPG is the active isomer of (RS)-MCPG (Cat.