1. PI3K/Akt/mTOR
  2. mTOR

mTOR

mTOR (mammalian target of Rapamycin) is a protein that in humans is encoded by the mTOR gene. mTOR is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription. mTOR belongs to the phosphatidylinositol 3-kinase-related kinase protein family. mTOR integrates the input from upstream pathways, including insulin, growth factors and amino acids. mTOR also senses cellular nutrient, oxygen, and energy levels. The mTOR pathway is dysregulated in human diseases, such as diabetes, obesity, depression, and certain cancers. Rapamycin inhibits mTOR by associating with its intracellular receptor FKBP12. The FKBP12-rapamycin complex binds directly to the FKBP12-Rapamycin Binding (FRB) domain of mTOR, inhibiting its activity.

mTOR Related Products (54):

Cat. No. Product Name Effect Purity
  • HY-10219
    Rapamycin Inhibitor 98.98%
    Rapamycin is a specific mTOR inhibitor with IC50 of 0.1 nM.
  • HY-10218
    Everolimus Inhibitor 98.53%
    Everolimus is a targeted, highly specific agent with an IC50 for binding to isolated FKBP-12, or FKBP-12 complexed to mTOR of 5 to 6 nM, and no significant activity against other protein kinases.
  • HY-13328
    INK-128 Inhibitor 99.06%
    INK-128 is a potent and selective mTOR inhibitor with IC50 of 1 nM, > 200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes.
  • HY-50673
    BEZ235 Inhibitor 98.83%
    BEZ235 is a dual pan-class I PI3K and mTOR kinase inhibitor with IC50 of 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR, respectively.
  • HY-16046
    AP1903 Modulator 98.25%
    AP1903 is a homodimer binding to FKBP, elicits potent and dose-dependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 0.1 nM.
  • HY-100470
    NSC781406 Inhibitor 99.55%
    NSC781406 is a highly potent PI3K and mTOR inhibitor with an IC50 of 2 nM for PI3Kα.
  • HY-U00326
    PI3Kα/mTOR-IN-1 Inhibitor
    PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα, respectively.
  • HY-U00141
    α-Hydroxylinoleic acid Inhibitor
    α-Hydroxylinoleic acid is an orally bioavailable inhibitor of mTOR.
  • HY-13003
    Torin 1 Inhibitor 99.16%
    Torin 1 is a potent inhibitor of mTOR, with IC50 values of 2 nM and 10 nM against mTORC1 and mTORC2, respectively.
  • HY-10422
    AZD-8055 Inhibitor 98.60%
    AZD-8055 is a novel ATP-competitive inhibitor of mTOR kinase activity, with an IC50 of 0.8 nM.
  • HY-13992
    AP20187 Modulator 99.80%
    AP20187 is a cell-permeable molecule used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
  • HY-B0795
    MHY1485 Activator 99.40%
    MHY1485 is a mTOR activator, which also is an inhibitor of autophagy.
  • HY-12513
    LY3023414 Inhibitor 99.70%
    LY3023414 potently and selectively inhibits class I PI3K isoforms, mTORC1/2, and DNA-PK with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 165 nM and 4.24 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, mTOR and DNA-PK, respectively.
  • HY-15247
    AZD2014 Inhibitor 98.99%
    AZD2014 is an ATP competitive mTOR inhibitor with IC50 of 2.81 nM.
  • HY-10474
    PP 242 Inhibitor
    PP 242 is the first selective and ATP competitive mTOR inhibitor with IC50 of 8 nM.
  • HY-10297
    GSK2126458 Inhibitor 99.31%
    GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively.
  • HY-15177
    PF-04691502 Inhibitor 99.49%
    PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity. PF-04691502 inhibits human and mouse PI3Kα with Ki of 1.8 and 1.2 nM, respectively, human PI3K isoforms β, δ, and γ with Ki of 2.1, 1.6, and 1.9 nM, respectively, and human mTOR with Ki of 16 nM.
  • HY-50910
    Temsirolimus Inhibitor 98.88%
    Temsirolimus is an inhibitor of mTOR with IC50 value of 1.76 μM.
  • HY-13002
    Torin 2 Inhibitor 99.89%
    Torin 2 is an mTOR inhibitor with EC50 of 0.25 nM for inhibiting cellular mTOR activity, and exhibits 800-fold selectivity over PI3K (EC50: 200 nM).
  • HY-50908
    Deforolimus Inhibitor 98.46%
    Deforolimus (AP23573; MK-8669) is a potent and selective mTOR inhibitor; inhibits S6 phosphorylation with an IC50 of 0.2 nM in HT-1080 cells.