1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR

nAChR

nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".

nAChR Related Products (36):

Cat. No. Product Name Effect Purity
  • HY-12560A
    PNU-282987 Agonist
    PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
  • HY-17418
    Vinblastine Inhibitor
    Vinblastine is a cytotoxic alkaloid used against various cancer types. Vinblastine inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
  • HY-14564A
    GTS-21 dihydrochloride Agonist
    GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation.
  • HY-N2332A
    Methyllycaconitine citrate Antagonist
    Methyllycaconitine citrate is a specific antagonist of α7 neuronal nicotinic acetylcholine receptor (α7nAChR).
  • HY-14774
    Monepantel Agonist
    Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.
  • HY-107675
    Desformylflustrabromine hydrochloride Agonist
    Desformylflustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48.
  • HY-12151
    NS 1738 Agonist
    NS1738 is a novel positive allosteric modulator of the α7 nAChR, with respect to positive modulation of α7 nAChR (EC50=3.4 μM in oocyte experiments).
  • HY-B1532
    Anabasine Agonist
    Anabasine is a nicotinic receptor agonist.
  • HY-12152
    PNU-120596 Agonist
    PNU-120596 (NSC 216666 ) is a potent and selective positive allosteric α7 nAChR modulator with an EC50 of 0.2 μM.
  • HY-15430A
    EVP-6124 hydrochloride Agonist
    EVP-6124 hydrochloride is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
  • HY-10019
    Varenicline Agonist
    Varenicline(CP 526555;Champix) is a selective α4β2 nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.
  • HY-B0569
    Hexamethonium Bromide Antagonist
    Hexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.
  • HY-14316A
    Tebanicline hydrochloride Modulator
    Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM.
  • HY-11013
    ZSET1446 Agonist
    ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.
  • HY-10932
    Aniracetam Modulator
    Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.
  • HY-N0252
    Catharanthine Inhibitor
    Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.
  • HY-B0429
    Pancuronium dibromide Antagonist
    Pancuronium Dibromide is a bis-quaternary steroid that is a competitive nicotinic antagonist.
  • HY-17555
    Meclofenoxate hydrochloride Inhibitor
    Meclofenoxate hydrochloride, an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general cognition.
  • HY-B0979
    Lobeline hydrochloride Agonist
    Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.
  • HY-B0118A
    Vecuronium bromide Inhibitor
    Vecuronium (bromide) is a muscle relaxant in the category of non-depolarizing blocking agents.