1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR

nAChR

nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".

nAChR Related Products (38):

Cat. No. Product Name Effect Purity
  • HY-12560A
    PNU-282987 Agonist 99.37%
    PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
  • HY-17418
    Vinblastine Inhibitor >98.0%
    Vinblastine is a cytotoxic alkaloid used against various cancer types. Vinblastine inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
  • HY-B1208
    Carbamoylcholine chloride Agonist >98.0%
    Carbamoylcholine chloride is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.
  • HY-14564A
    GTS-21 dihydrochloride Agonist 99.66%
    GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation.
  • HY-106268A
    Larazotide acetate Antagonist 99.53%
    Larazotide acetate (AT-1001) is a high affinity and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist with an IC50 of 35.2 nM.
  • HY-107675
    Desformylflustrabromine hydrochloride Agonist
    Desformylflustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48.
  • HY-12151
    NS 1738 Agonist
    NS1738 is a novel positive allosteric modulator of the α7 nAChR, with respect to positive modulation of α7 nAChR (EC50=3.4 μM in oocyte experiments).
  • HY-B1532
    Anabasine Agonist 98.71%
    Anabasine is a nicotinic receptor agonist.
  • HY-14774
    Monepantel Agonist 99.43%
    Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.
  • HY-10019
    Varenicline Agonist 99.98%
    Varenicline(CP 526555;Champix) is a selective α4β2 nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.
  • HY-12152
    PNU-120596 Agonist 99.22%
    PNU-120596 (NSC 216666 ) is a potent and selective positive allosteric α7 nAChR modulator with an EC50 of 0.2 μM.
  • HY-B0429
    Pancuronium dibromide Antagonist >98.0%
    Pancuronium Dibromide is a bis-quaternary steroid that is a competitive nicotinic antagonist.
  • HY-14316A
    Tebanicline hydrochloride Modulator 98.00%
    Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM.
  • HY-11013
    ZSET1446 Agonist 98.03%
    ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.
  • HY-N2332A
    Methyllycaconitine citrate Antagonist >98.0%
    Methyllycaconitine citrate is a specific antagonist of α7 neuronal nicotinic acetylcholine receptor (α7nAChR).
  • HY-B0569
    Hexamethonium Bromide Antagonist >98.0%
    Hexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.
  • HY-10932
    Aniracetam Modulator 99.43%
    Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.
  • HY-N0252
    Catharanthine Inhibitor 99.88%
    Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.
  • HY-15430A
    EVP-6124 hydrochloride Agonist 98.20%
    EVP-6124 hydrochloride is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
  • HY-B0827
    Dinotefuran Inhibitor 99.92%
    Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors.