1. MAPK/ERK Pathway
  2. p38 MAPK

p38 MAPK

p38 MAPK (p38 mitogen-activated protein kinase) is a class of mitogen-activated protein kinases that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, andosmotic shock, and are involved in cell differentiation, apoptosis and autophagy. p38 MAPK is the mammalian orthologue of the yeast Hog1p MAP kinase, which participates in a signaling cascade controlling cellular responses to cytokines and stress. Four p38 MAPK, p38-α (MAPK14), -β (MAPK11), -γ (MAPK12/ERK6), and -δ (MAPK13/SAPK4), have been identified. Similar to the SAPK/JNK pathway, p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), ultraviolet light, and growth factors.

p38 MAPK Related Products (34):

Cat. No. Product Name Effect Purity
  • HY-10256
    SB 203580 Inhibitor 99.54%
    SB 203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
  • HY-10295
    SB 202190 Inhibitor 99.88%
    SB 202190 inhibits p38 and p38β2 with IC50 values of 50 nM and 100 nM. respectively.
  • HY-10256A
    SB 203580 hydrochloride Inhibitor 99.71%
    SB 203580 hydrochloride is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM.
  • HY-10320
    Doramapimod Inhibitor 99.40%
    Doramapimod is a highly potent p38α inhibitor with an IC50 of 4 nM, also inhibits B-Raf with an IC50 of 83 nM and Abl with an IC50 of 14.6 μM.
  • HY-13241
    LY2228820 Inhibitor 99.94%
    LY2228820 is a novel and potent inhibitor of p38 MAPK with IC50 of 7 nM in a cell-free assay, but does not alter p38 MAPK activation.
  • HY-19562
    PF-06260933 Inhibitor 99.69%
    PF-06260933 is a highly selective small-molecule inhibitor of MAP4K4 with IC50s of 3.7 and 160 nM for kinase and cell, respectively.
  • HY-18874
    p38-α MAPK-IN-1 Inhibitor 99.92%
    p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.
  • HY-U00324
    p38 MAPK-IN-2 Inhibitor
    p38 MAPK-IN-2 is an inhibitor of p38 kinase.
  • HY-12048
    Chelerythrine Chloride Inhibitor >98.0%
    Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C and mitogen-activated protein kinase (MAPK), with IC50 of 660 nM for PKC, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
  • HY-10402
    Losmapimod Inhibitor
    Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.
  • HY-100343
    GNE-495 Inhibitor 98.79%
    GNE-495 is a potent and Selective MAP4K4 Inhibitor with IC50 of 3.7 nM.
  • HY-10578
    PD 169316 Inhibitor
    PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM.
  • HY-10328
    VX-745 Inhibitor 98.74%
    VX-745 is a potent and selective inhibitor of p38α, and possesses anti-inflammatory activity.
  • HY-10406
    SCIO-469 Inhibitor 98.07%
    SCIO-469 is a selective ATP-competitive p38 inhibitor with IC50 of 9 nM for p38αin vitro, about 10-fold selectivity for p38α over p38β, and at least 2000-fold selectivity for p38α over an in vitro panel of 20 other kinases, including other MAK kinases.
  • HY-10401
    VX-702 Inhibitor 99.54%
    VX-702 is a highly selective inhibitor of p38α MAPK(IC50=4 -20 nM), 14-fold higher potency against the p38α versus p38β.
  • HY-11068
    SB 239063 Inhibitor 99.32%
    SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α).
  • HY-10456
    TAK-715 Inhibitor 99.93%
    TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
  • HY-15027
    5-Aminosalicylic acid Inhibitor >98.0%
    5-Aminosalicylic acid is an anti-inflammatory compound.
  • HY-14305A
    BMS-582949 hydrochloride Inhibitor 98.83%
    BMS-582949 hydrochloride is a novel highly selective p38α MAPK inhibitor, inhibits p38α with IC50 of 13 nM.
  • HY-14975
    R1487 Hydrochloride Inhibitor 98.68%
    R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α.