1. Cell Cycle/DNA Damage
  2. p97

p97

p97, an abundant hexameric ATPase of the AAA family, is involved in homotypic membrane fusion. It is thought to disassemble SNARE complexes formed during the process of membrane fusion. Two structures have been reported: a crystal structure of the N-terminal and D1 ATPase domains of murine p97 at 2.9 A resolution, and a cryoelectron microscopy structure of full-length rat p97 at 18 A resolution. Together, these structures show that the D1 and D2 hexamers pack in a tail-to-tail arrangement, and that the N domain is flexible. A comparison with NSF D2 (ATP complex) reveals possible conformational changes induced by ATP hydrolysis.

p97 Related Products (6):

Cat. No. Product Name Effect Purity
  • HY-12861
    CB-5083 Inhibitor 99.49%
    CB-5083 is a potent, selective and orally bioavailable p97 inhibitor with an IC50 value of 11 nM.
  • HY-15713
    NMS-873 Inhibitor 99.93%
    NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 20 nM (Wild Type, 1 mM ATP).
  • HY-19797A
    ML241 hydrochloride Inhibitor 99.98%
    ML241 hydrochloride is a potent and selective inhibitors of p97 ATPase with IC50 values of 100 nM.
  • HY-19795
    ML240 Inhibitor 99.49%
    ML240 is a selective, ATP-competitive p97 inhibitor with IC50 values of 100 nM.
  • HY-15714
    NMS-859 Inhibitor 98.58%
    NMS-859 is a potent and specific small molecule covalent inhibitor of the ATPase VCP/p97 (IC50 ~0.37 (mu)M), identified by high-throughput screening.
  • HY-15945
    DBeQ Inhibitor 98.84%
    DBeQ(JRF-12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 (mu)M.