2. Epigenetics
  3. SF3B1

SF3B1

SF3B1 is the largest subunit of the spliceosome factor 3b (SF3B) complex and functions by serving as a core component of the 17S U2 SnRNP complex of the spliceosome. The spliceosome removes introns from precursor mRNA (premRNA) and generates mature, spliced mRNAs. SF3B1 mutations induce common and tumor-specific splicing aberrations[1].

SF3B1 Related Products (6):

Cat. No. Product Name Effect Purity
  • HY-141881
    PROTAC-O4I2 Degrader 99.66%
    PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells[1].
  • HY-111517
    H3B-8800 Inhibitor 98.85%
    H3B-8800 is a potent and orally active SF3B splicing modulator. H3B-8800 direct interaction with the SF3b complex and shows anti-cancer activity. H3B-8800 has the potential for the research of acute myeloid leukemia (AML) with SF3B1 mutant[1].
  • HY-16399
    Pladienolide B Inhibitor
    Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B induces apoptosis[1][2][3].
  • HY-16466
    Spliceostatin A
    Spliceostatin A, the FR901464 (HY-16212) methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding SF3B1. SF3B1 is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells[1][2][3].
  • HY-133924
    18-Deoxyherboxidiene Inhibitor
    18-Deoxyherboxidiene (RQN-18690A) is a potent angiogenesis inhibitor. 18-Deoxyherboxidiene targets SF3b, a spliceosome component that is a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidiene inhibits the migration and tube formation of human umbilical vein endothelial cells (HUVECs) without significant cell toxicity. 18-Deoxyherboxidiene has the potential for cancer research[1].
  • HY-RS23526
    Sf3b1 Rat Pre-designed siRNA Set A
    Sf3b1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sf3b1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.