Small Interfering RNA (siRNA)

Small Interfering RNA (siRNA) is a small exogenous double-stranded RNA (dsRNA) (20-25 nucleotides), which triggers the RNA interference (RNAi) pathway. The short dsRNA unwinds and the sense strand is degraded. Antisense strand forms RNA induced silencing complex (RISC) with various protein components. The antisense strand retained in RISC is specifically complementary to the target gene mRNA. Meanwhile, RISC has nuclease activity, which can cut and degrade the target gene mRNA, and inhibit the expression of target gene. Incomplete complementarity results in mRNA translation inhibition.

Small Interfering RNA (siRNA) Related Products (29530):

By Effects:	Pre-designed Setss (27581) Inhibitors (8)

Cat. No.	Product Name	Effect	Purity

HY-150150

SiRNA Negative Control
SiRNA Negative Control is a siRNA of 21 nucleotides, and can be used as a negative control.

HY-132591

Inclisiran		98.10%
Inclisiran is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran inhibits the transcription of PCSK9. Inclisiran inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran can be used in researches of hyperlipidemia and cardiovascular disease (CVD)^[1]^[2]^[3].

HY-132609

Patisiran sodium		99.09%
Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis^[1]^[2]^[3].

HY-132591A

Inclisiran sodium		98.10%
Inclisiran sodium is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran sodium inhibits the transcription of PCSK9. Inclisiran sodium inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran sodium has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran sodium can be used in researches of hyperlipidemia and cardiovascular disease (CVD)^[1]^[2]^[3].

HY-132610

Givosiran		98.51%
Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. Givosiran can be used for the research of acute intermittent porphyria^[1]^[2].

HY-RS29175

Mylk3 Rat Pre-designed siRNA Set A
Mylk3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mylk3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS28887

Zup1 Rat Pre-designed siRNA Set A
Zup1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Zup1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS28657

Dgki Rat Pre-designed siRNA Set A
Dgki Rat Pre-designed siRNA Set A contains three designed siRNAs for Dgki gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09541

NR2F1 Human Pre-designed siRNA Set A	Pre-designed Sets
NR2F1 Human Pre-designed siRNA Set A contains three designed siRNAs for NR2F1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06801

IMPG2 Human Pre-designed siRNA Set A	Pre-designed Sets
IMPG2 Human Pre-designed siRNA Set A contains three designed siRNAs for IMPG2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06755

IL31RA Human Pre-designed siRNA Set A	Pre-designed Sets
IL31RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL31RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04496

ERI1 Human Pre-designed siRNA Set A	Pre-designed Sets
ERI1 Human Pre-designed siRNA Set A contains three designed siRNAs for ERI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06794

IMP4 Human Pre-designed siRNA Set A	Pre-designed Sets
IMP4 Human Pre-designed siRNA Set A contains three designed siRNAs for IMP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS20081

Pias1 Mouse Pre-designed siRNA Set A	Pre-designed Sets
Pias1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pias1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10864

POM121 Human Pre-designed siRNA Set A	Pre-designed Sets
POM121 Human Pre-designed siRNA Set A contains three designed siRNAs for POM121 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS25996

Bcap31 Rat Pre-designed siRNA Set A	Pre-designed Sets
Bcap31 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcap31 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS29185

Nat8l Rat Pre-designed siRNA Set A
Nat8l Rat Pre-designed siRNA Set A contains three designed siRNAs for Nat8l gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS19036

Smad9 Mouse Pre-designed siRNA Set A	Pre-designed Sets
Smad9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smad9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS13474

SNAP25 Human Pre-designed siRNA Set A	Pre-designed Sets
SNAP25 Human Pre-designed siRNA Set A contains three designed siRNAs for SNAP25 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS10731

PLP1 Human Pre-designed siRNA Set A	Pre-designed Sets
PLP1 Human Pre-designed siRNA Set A contains three designed siRNAs for PLP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.