1. Epigenetics
  2. Small Interfering RNA (siRNA)

Small Interfering RNA (siRNA)

Small Interfering RNA (siRNA) is a small exogenous double-stranded RNA (dsRNA) (20-25 nucleotides), which triggers the RNA interference (RNAi) pathway. The short dsRNA unwinds and the sense strand is degraded. Antisense strand forms RNA induced silencing complex (RISC) with various protein components. The antisense strand retained in RISC is specifically complementary to the target gene mRNA. Meanwhile, RISC has nuclease activity, which can cut and degrade the target gene mRNA, and inhibit the expression of target gene. Incomplete complementarity results in mRNA translation inhibition.

Small Interfering RNA (siRNA) Related Products (16207):

Cat. No. Product Name Effect Purity
  • HY-150150
    SiRNA Negative Control
    SiRNA Negative Control is a siRNA of 21 nucleotides, and can be used as a negative control.
  • HY-132591
    Inclisiran
    Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9. Inclisiran can be used for hyperlipidemia and cardiovascular disease (CVD) research[1].
  • HY-132609
    Patisiran sodium
    Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis[1][2][3].
  • HY-132591A
    Inclisiran sodium 98.10%
    Inclisiran sodium is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9. Inclisiran sodium can be used for hyperlipidemia and cardiovascular disease (CVD) research[1].
  • HY-132610
    Givosiran
    Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. Givosiran can be used for the research of acute intermittent porphyria[1][2].
  • HY-RS16221
    Nphs1 Mouse Pre-designed siRNA Set A

    Nphs1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nphs1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

  • HY-161436
    TPA-dT
    TPA-dT is a thymidine analog with a tris[(2-pyridyl)methyl]amine (TPA) group. TPA-dT can be used to modify siRNAs. The TPA-modified siRNAs remain functionally inactive and is incapable of silencing gene expression until the TPA moiety is removed upon exposure to Cu(I)[1].
  • HY-RS16222
    Crk Mouse Pre-designed siRNA Set A

    Crk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Crk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

  • HY-RS09541
    NR2F1 Human Pre-designed siRNA Set A

    NR2F1 Human Pre-designed siRNA Set A contains three designed siRNAs for NR2F1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

  • HY-RS06801
    IMPG2 Human Pre-designed siRNA Set A

    IMPG2 Human Pre-designed siRNA Set A contains three designed siRNAs for IMPG2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

  • HY-RS06755
    IL31RA Human Pre-designed siRNA Set A

    IL31RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL31RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

  • HY-RS04496
    ERI1 Human Pre-designed siRNA Set A
    ERI1 Human Pre-designed siRNA Set A contains three designed siRNAs for ERI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-RS06794
    IMP4 Human Pre-designed siRNA Set A

    IMP4 Human Pre-designed siRNA Set A contains three designed siRNAs for IMP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

  • HY-RS10864
    POM121 Human Pre-designed siRNA Set A

    POM121 Human Pre-designed siRNA Set A contains three designed siRNAs for POM121 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

  • HY-RS13474
    SNAP25 Human Pre-designed siRNA Set A

    SNAP25 Human Pre-designed siRNA Set A contains three designed siRNAs for SNAP25 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

  • HY-RS10731
    PLP1 Human Pre-designed siRNA Set A

    PLP1 Human Pre-designed siRNA Set A contains three designed siRNAs for PLP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

  • HY-RS15264
    TUBGCP4 Human Pre-designed siRNA Set A

    TUBGCP4 Human Pre-designed siRNA Set A contains three designed siRNAs for TUBGCP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

  • HY-RS10929
    Ppargc1a Mouse Pre-designed siRNA Set A

    Ppargc1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppargc1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

  • HY-RS02529
    CEP95 Human Pre-designed siRNA Set A

    CEP95 Human Pre-designed siRNA Set A contains three designed siRNAs for CEP95 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

  • HY-RS05797
    GRIFIN Human Pre-designed siRNA Set A

    GRIFIN Human Pre-designed siRNA Set A contains three designed siRNAs for GRIFIN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.