2. Epigenetics
  3. TET Protein

TET Protein

TET proteins, including TET1, TET2, and TET3, are a family of dioxygenases that catalyze the demethylation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), facilitating DNA demethylation. These enzymes share a common core catalytic domain at their C termini. TET3 is highly expressed in oocytes and fertilized zygotes but decreases during cleavage, while TET1 and TET2 expression increases during pre-implantation development. TET1 is crucial for development and intestinal stem cell function. TET2 mutations are frequently found in hematologic malignancies, such as myelodysplastic syndrome and acute myeloid leukemia. TET3 plays a significant role in demethylation processes, including zygote formation, embryogenesis, axon regeneration, and synaptic transmission[1][2].

TET Protein Related Products (8):

Cat. No. Product Name Effect Purity
  • HY-402410
    TETi76 Inhibitor
    TETi76 is an orally active TET family inhibitor with IC50 values ??of 1.5, 9.4 and 8.8 μM for TET1, TET2 and TET3, respectively. TETi76 competitively binds to the active site of TET enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of TET2 mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research[1].
  • HY-12303
    OAC1 Activator 99.56%
    OAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time[1][2].
  • HY-111558A
    Bobcat339 hydrochloride Inhibitor 99.59%
    Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1].
  • HY-122258
    NSC-370284 Inhibitor 99.27%
    NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5[1].
  • HY-111558
    Bobcat339 Inhibitor 99.44%
    Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription[1].
  • HY-W396714
    Succinic acid sodium Inhibitor
    Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of KCNMB1 (potassium channel subunit β1) and TET1 (ten?eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research[1][2][3].
  • HY-120395
    UC-514321 Inhibitor
    UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity[1].
  • HY-160638
    NSC-311068 Inhibitor
    NSC-311068 is TET1 inhibitor. NSC-311068 selectively suppress TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification. NSC-311068 represses the level of TET1 expression and the global 5hmC level. NSC-311068 effectively inhibits cell viability in AML cells with high expression of TET1[1].