2. Anti-infection
  3. Virus Protease

Virus Protease

Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.

Virus Protease Related Products (135):

Cat. No. Product Name Effect Purity
  • HY-A0281
    4-Phenylbutyric acid Inhibitor
    4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
  • HY-15304
    Dynasore Inhibitor 99.85%
    Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 μM. Dynasore blocks cell migration.
  • HY-18234A
    Leupeptin hemisulfate Inhibitor
    Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].
  • HY-108325
    Brequinar Inhibitor 99.75%
    Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. Brequinar also has an anti-SARS2 activity.
  • HY-14654
    Aspirin Inhibitor
    Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis[1][2][3][4][5][6].
  • HY-N0470S8
    L-Lysine-1,2,3,4,5,6(hydrochloride (1:1))-13C6
    L-Lysine-1,2,3,4,5,6(hydrochloride (1:1))-13C6 is the 13C labeled L-Lysine hydrochloride[1]. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health[2][3][4].
  • HY-N0354S
    Anthraquinone-d8
    Anthraquinone-d8 is the deuterium labeled Anthraquinone[1]. Anthraquinone is used as a precursor for dye formation.
  • HY-W012835S1
    4-Methylanisole-d3
    4-Methylanisole-d3 is the deuterium labeled 4-Methylanisole[1]. 4-Methylanisole (4-Methoxytoluene) is food flavoring agent and can be naturally found in Ylang Ylang fragrance oil[2].
  • HY-136466
    A2ti-2 Inhibitor 99.85%
    A2ti-2 is a selective and low-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 230 μM[1]. A2ti-2 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-2 prevents human papillomavirus type 16 (HPV16) infection[2].
  • HY-136149A
    Mpro inhibitor N3 hemihydrate Inhibitor
    Mpro inhibitor N3 hemihydrate is a potent inhibitor of SARS-CoV-2 Mpro with an EC50 of 16.77 μM for SARS-CoV-2. Mpro inhibitor N3 hemihydrate specifically inhibits Mpro from multiple coronaviruses, including SARS-CoV and MERS-CoV. Mpro inhibitor N3 hemihydrate displays inhibition against HCoV-229E, FIPV, and MHV-A59 with individual IC50 of 4.0 μM, 8.8 μM, and 2.7 μM, respectively[1][2].
  • HY-150600
    NS2B/NS3-IN-7 Inhibitor
    NS2B/NS3-IN-7 (compound 26) is a highly potent Zika virus NS2B-NS3 protease inhibitor with a Ki value of 2.33 nM. NS2B/NS3-IN-7 can reduce amounts of ZIKV-infected cells[1].
  • HY-A0281S3
    4-Phenylbutyric acid-d2
    4-Phenylbutyric acid-d2 is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
  • HY-N0469S
    L-Lysine-d3 hydrochloride Inhibitor
    L-Lysine-d3 (hydrochloride) is the deuterium labeled L-Lysine. L-lysine is an essential amino acid[1][2] with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions[2].
  • HY-N0470S3
    L-Lysine-13C6,15N2 hydrochloride Inhibitor
    L-Lysine-13C6,15N2 (hydrochloride) is the 13C- and 15N-labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
  • HY-N0289
    Lycorine hydrochloride Inhibitor 99.89%
    Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity[1]. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM)[2].
  • HY-N0184
    Glycyrrhizic acid Inhibitor
    Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.
  • HY-N0693
    Schisandrin A Inhibitor 99.43%
    Schisandrin A inhibits CYP3A activity with an IC50 of 6.60 μM and Ki of 5.83 μM, respectively.
  • HY-N0731
    Genkwanin Inhibitor 99.82%
    Genkwanin is a major non-glycosylated flavonoid with anti-flammatory activities.
  • HY-136465
    A2ti-1 Inhibitor 99.83%
    A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 24 μM[1]. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16) infection[2].
  • HY-B0388
    Probucol Inhibitor
    Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.