1. Screening Libraries
  2. Epigenetics Compound Library

Epigenetics Compound Library

(668 compounds) Cat. No.: HY-L005
Library Contents: XLSX PDF

Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. Many types of epigenetic processes have been identified, including DNA methylation, alteration in the structure of histone proteins and gene regulation by small noncoding microRNAs. Modification of DNA, protein, or RNA, resulting in changes to the function and/or regulation of these molecules, without altering their primary sequences, reveals the complexities of cellular differentiation, embryology, the regulation of gene expression, aging, cancer, and other diseases.

MCE provide a unique collection of 668 epigenetics-related compounds that can be used in the research of the related diseases.

Size (Pre-dissolved DMSO or Solid) Price Stock
30 μL/well (10 mM solution) Get quote In-stock
50 μL/well (10 mM solution) Get quote In-stock
100 μL/well (10 mM solution) Get quote In-stock
250 μL/well (10 mM solution) Get quote In-stock

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  • Description

  • Product Details

  • Composition

  • Contents

  • Documentation

Description
& Advantages

•   A unique collection of 668 small molecule modulators with biological activity used for epigenetics research and associated assays.

•   The library contains epigenetics-related compounds targeting HDAC, Histone Demethylase, Histone Acetyltransferase (HAT), DNA Methyltransferase (DNMT), Epigenetic Reader Domain, MicroRNA, etc.

•   A valuable tool for chemical genomics, epigenetic target identification in pharmacogenomics, and other biological applications.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Rich documentation with structure, IC50, and other chemical & biological data.

•   NMR and HPLC validated to ensure the highest purity.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 668 epigenetics related compounds supplied as pre-dissolved Solutions or Solid
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Composition

Contents of Epigenetics Compound Library

Plate layout: HY-L005-1

1 2 3 4 5 6 7 8 9 10 11 12
a Empty HLCL-61 (hydrochloride) EPZ015866 NKL 22 AZD1152-HQPA AZD1152 ZM-447439 Veliparib (dihydrochloride) Tozasertib Olaparib MLN8054 Empty
b Empty AZD-1480 Vorinostat CUDC-101 Panobinostat Belinostat Fasudil (Hydrochloride) Enzastaurin Sotrastaurin TG-101348 TG101209 Empty
c Empty Tasquinimod Valproic acid (sodium salt) BIX-01294 A-966492 Rucaparib (phosphate) MK-4827 MK-4827 (tosylate) CCT 137690 UNC0321 CYT387 Empty
d Empty CYT387 (sulfate salt) Alisertib ENMD-2076 (Tartrate) ENMD-2076 PCI-24781 KU-57788 CGP60474 WHI-P97 AG-490 SNS-314 Empty
e Empty BSI-201 INO-1001 Chelerythrine Chloride CCT129202 Hesperadin Entinostat Mocetinostat TAK-901 MM-102 (trifluoroacetate) IOX1 Empty
f Empty HTH-01-015 UNC0379 G007-LK Decernotinib OF-1 A-366 ZM39923 (hydrochloride) SP2509 ML324 GSK503 Empty
g Empty AZ6102 (+)-JQ-1 (R)-(-)-JQ1 Enantiomer GSK 525762A LY2784544 I-BET151 MK-5108 AMG 900 Droxinostat Tubastatin A (Hydrochloride) Empty
h Empty Tubastatin-A Pracinostat AICAR Dorsomorphin (dihydrochloride) Zebularine Tenovin-1 GSK126 M344 Sirtinol AZD-2461 Empty

Plate layout: HY-L005-2

1 2 3 4 5 6 7 8 9 10 11 12
a Empty Dacinostat RG108 Lomeguatrib PJ34 (hydrochloride) Zoledronic acid (monohydrate) EPZ-6438 UNC0646 UNC 0631 MK-8745 C646 Empty
b Empty Ro 31-8220 (mesylate) WHI-P154 RGFP966 JIB-04 MS436 GSK1324726A SGI-1027 JW 55 UPF 1069 PF-03814735 Empty
c Empty Reversine SRT 1720 (Hydrochloride) XAV-939 SB1317 EPZ004777 SRT 2104 UNC0638 WP1066 Baricitinib Baricitinib (phosphate) Empty
d Empty CEP-33779 EX-527 Scriptaid JANEX-1 EI1 EPZ-5676 UNC1999 BRD9539 GSK-J1 GSK-J2 Empty
e Empty GSK-J4 UNC1215 SGC0946 Sodium phenylbutyrate GSK2801 OTX-015 XL228 WZ4003 Bromosporine UNC 669 Empty
f Empty CPI-203 Inauhzin C-7280948 CPI-169 racemate Cerdulatinib 4SC-202 (free base) ACY-1215 RG2833 PFI-1 RVX-208 Empty
g Empty BRD4770 Remodelin (hydrobromide) ZLN024 (hydrochloride) Solcitinib MC1568 EPZ011989 OICR-9429 GLPG0634 TMP269 PFI-2 (hydrochloride) Empty
h Empty GSK2879552 PFI-4 GSK-5959 BRD73954 BG45 AMI-1 TAS-301 I-BRD9 UF010 LMK-235 Empty

Plate layout: HY-L005-3

1 2 3 4 5 6 7 8 9 10 11 12
a Empty LLY-507 WDR5-0103 Pimelic Diphenylamide 106 BML-210 MN-64 Pimelic Diphenylamide 106 (analog) Peficitinib MS023 SGC707 SID 3712249 Empty
b Empty Tofacitinib (citrate) AT9283 A-769662 BI 2536 Ruxolitinib Ruxolitinib (phosphate) CI-994 GSK-1070916 Aurora A inhibitor I JQ-1 (carboxylic acid) Empty
c Empty Decitabine Sodium Butyrate Amodiaquin (dihydrochloride dihydrate) Parthenolide Empty Empty Empty Empty Empty Empty Empty
d Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty
e Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty
f Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty
g Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty
h Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty
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