Fragment Library

(22,731) Cat. No.: HY-L032: Library Contents: XLSX PDF

Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function; it can cover broad swaths of chemical space and allows the use of creative chemistry. Fragment-based drug discovery is well-established in industry and has resulted in a variety of drugs entering clinical trials, with two, vemurafenib and venetoclax, already approved. FBDD also has key attractions for academia. Notably, it is able to tackle difficult or novel targets for which no chemical matter may be found in existing HTS collections.

MCE designs a unique collection of 22,731 fragment compounds, all of which obey a heuristic rule called the “Rule of Three (RO3) ”, in which molecular weight ≤300 Da, the number of hydrogen bond donors (H-donors) ≤3, the number of hydrogen bond acceptors (H-acceptors) is ≤3 and cLogP is ≤3. This library is an important source of lead-like drugs.

Size (Pre-dissolved DMSO or Solid)	Price	Stock
30 μL/well (10 mM solution)	Get quote	In-stock
50 μL/well (10 mM solution)	Get quote	In-stock
100 μL/well (10 mM solution)	Get quote	In-stock
250 μL/well (10 mM solution)	Get quote	In-stock

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Description
Product Details
Composition
Contents
Documentation

Description
& Advantages

• A unique collection of 22,731 fragment compounds for traditional lead identification via high-throughput screening (HTS).

• The compounds follow the Rule of Three.

• A useful tool for the fragment-based approach to drug discovery (FBDD).

• More detailed compound information with structure, Molecular Weight, cLogP, H-donor and H-acceptor number.

• NMR and HPLC validated ensure high purity.

• All compounds are in stock and continuously updated.

Parameter	Range	Average Value
Molecular Weight	≤300	181.63
cLogP	≤3.0	1.6154
H-donors	≤3.0	2.07
H-acceptors	≤3.0	0.78

Product Details

Formulation:: A collection of 22,731 fragment compounds supplied as pre-dissolved Solutions or Solid
Container:: 96- or 384-well Plate with Peelable Foil Seal
Storage:: -80°C
Shipping:: Blue ice or dry ice

Composition

Contents of Fragment Library

Documentation

XLSX (0 KB) PDF (0 KB) Library Handling Instructions ( KB)

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