1. Screening Libraries
  2. GPCR/G Protein Compound Library

GPCR/G Protein Compound Library

(1961 compounds) Cat. No.: HY-L006
Library Contents: XLSX PDF

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. GPCRs play an important role in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third to one-half of all approved drugs act by binding to GPCRs. GPCRs are a large group of drug targets in drug discovery.

MCE provides a unique collection of 1961 small molecules targeting GPCRs that can be used in the screening for various GPCRs-related research and drug development projects.

Size (Pre-dissolved DMSO or Solid) Price Stock
30 μL/well (10 mM solution) Get quote In-stock
50 μL/well (10 mM solution) Get quote In-stock
100 μL/well (10 mM solution) Get quote In-stock
250 μL/well (10 mM solution) Get quote In-stock

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  • Description

  • Product Details

  • Composition

  • Contents

  • Documentation

& Advantages

•   A unique collection of 1961 small molecules targeting G protein coupled receptors used in GPCR screening for various research and drug development projects.

•   Targets such as 5-HT Receptor, Dopamine Receptor, Opioid Receptor, Adrenergic Receptors, Cannabinoid Receptor, mGluR, ETA Receptor, etc.

•   The most successful class of drugable targets in the human genome and remain the most attractive family of targets.

•   All of the small molecules in the GPCR library are well characterized with biological and pharmaceutical activity. Some compounds have been approved by the FDA.

•   A powerful tool for discovering GPCR-based drugs that are the richest signal receptor targets for drug discovery.

•   Structurally diverse, medicinally active, and cell permeable.

•   Rich documentation with structure, IC50, and brief introduction.

•   NMR and HPLC validated to ensure the highest purity.

•   All compounds are in stock and continuously updated.

Product Details
A collection of 1961 GPCR/G Protein related compounds supplied as pre-dissolved Solutions or Solid
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Blue ice

Contents of GPCR/G Protein Compound Library

Plate layout: HY-L006-1

1 2 3 4 5 6 7 8 9 10 11 12
a Empty PD 117519 NPS-2143 Taranabant 4-IBP Ro 67-7476 TCS-OX2-29 Plerixafor Bay 59-3074 Aprepitant Ticagrelor Empty
b Empty Zibotentan Vorapaxar Silodosin NPS-2143 (hydrochloride) SCH 527123 PD 123319 (ditrifluoroacetate) MK-3207 (Hydrochloride) MK-2894 SKF-82958 (hydrobromide) TAK-875 Empty
c Empty JDTic (dihydrochloride) Sarpogrelate (hydrochloride) Ponesimod Palosuran MK-6892 CJ-42794 Almorexant (hydrochloride) Otenabant Istradefylline SB-334867 (free base) Empty
d Empty SB-674042 TCS 1102 Tozadenant Risperidone Asenapine (maleate) Sitaxsentan (sodium) Fingolimod (hydrochloride) GSK1292263 BX471 Pitolisant (hydrochloride) Empty
e Empty Ozanimod MK-3697 IBMX Siponimod Atipamezole (hydrochloride) Angiotensin (1-7) 6H05 (trifluoroacetate) SKF 38393 (hydrochloride) Gonadorelin (acetate) Y16 Empty
f Empty Prucalopride (succinate) ML141 EHop-016 RBC8 CASIN BQU57 SRT3190 ADL-5859 ADX-47273 MRS 2578 Empty
g Empty WAY-100635 (maleate salt) CGS 21680 (Hydrochloride) Biperiden (Hydrochloride) MTEP (hydrochloride) Ambrisentan BRL 54443 BAN ORL 24 PF-4136309 JTC-801 Ki16425 Empty
h Empty Org 27569 WIN 55,212-2 (Mesylate) Montelukast (sodium) VU0152100 SB 242084 Xanomeline (oxalate) JNJ-7777120 SA4503 (dihydrochloride) Rupatadine (Fumarate) LY310762 Empty

Plate layout: HY-L006-2

1 2 3 4 5 6 7 8 9 10 11 12
a Empty Betamethasone Beclometasone dipropionate Blonanserin Budesonide Clobetasol propionate Deflazacort Leuprolide (Acetate) Mometasone furoate MSX-122 Noscapine Empty
b Empty LY 344864 Angiotensin II human ICI 118,551 (hydrochloride) Telmisartan ZCL278 AMG 837 (calcium hydrate) UNC0642 CCG-1423 Rimonabant (Hydrochloride) Aclidinium (Bromide) Empty
c Empty Cisapride Prucalopride Tegaserod (maleate) Macitentan Vilazodone (Hydrochloride) Vilazodone Cimetidine Indacaterol (maleate) SB 271046 (Hydrochloride) SB-742457 Empty
d Empty AC-55541 Fosaprepitant (dimeglumine) VU0361737 Bilastine Haloperidol Olanzapine Quetiapine Amisulpride Aripiprazole Talnetant Empty
e Empty Pimavanserin Tandospirone TBPB MPEP (Hydrochloride) CPPHA Anamorelin Salirasib Cariprazine (hydrochloride) Mirabegron Adoprazine Empty
f Empty Tasimelteon Tarafenacin (D-tartrate) Lasmiditan (hydrochloride) NS-304 Taprenepag Azilsartan Avosentan ST-836 (hydrochloride) Reparixin (L-lysine salt) Prasugrel Empty
g Empty Ciproxifan (maleate) MBX-2982 Cabergoline OC000459 Lorcaserin (Hydrochloride) SB-269970 (hydrochloride) VU 0357121 rac-Rotigotine (Hydrochloride) Vortioxetine Vortioxetine (hydrobromide) Empty
h Empty RS 504393 RS 127445 BML-190 AM630 AM251 CTEP MDA 19 WZ811 Ebrotidine CP-809101 (hydrochloride) Empty

Plate layout: HY-L006-3

1 2 3 4 5 6 7 8 9 10 11 12
a Empty AR 231453 APD668 Piboserod GW9508 Kobe0065 kobe2602 SB-222200 NSC 23766 (trihydrochloride) Brexpiprazole Eprosartan (mesylate) Empty
b Empty AdipoRon AMD 3465 (hexahydrobromide) AM095 AM095 (free acid) Diphenmanil (methylsulfate) UNBS5162 Asenapine (hydrochloride) Setipiprant EHT 1864 Oncrasin-1 Empty
c Empty RU 24969 CID 16020046 SB225002 Grapiprant TG6-10-1 BD-1047 (dihydrobromide) Tolvaptan Olmesartan (medoxomil) Dexmedetomidine (hydrochloride) Medetomidine (hydrochloride) Empty
d Empty Agomelatine Alcaftadine Cetirizine (dihydrochloride) Loratadine Pramipexole (dihydrochloride) Loteprednol Etabonate Tiotropium (Bromide) Octreotide (acetate) Clozapine (N-oxide) Desmopressin (Acetate) Empty
e Empty (S)-Timolol (Maleate) Metoclopramide Metoclopramide (hydrochloride hydrate) Loxapine Loxapine (succinate) Strontium Ranelate Alarelin (Acetate) Ziprasidone (hydrochloride monohydrate) Iloperidone Guanfacine (hydrochloride) Empty
f Empty Naloxone (hydrochloride) Tripelennamine (hydrochloride) Salmeterol (xinafoate) Clopidogrel (hydrogen sulfate) Cortisone (acetate) Prednisolone Glycopyrrolate Meptazinol (hydrochloride) Zafirlukast Carteolol (hydrochloride) Empty
g Empty Acebutolol (hydrochloride) Atenolol Bambuterol (hydrochloride) Metoprolol (Succinate) Candesartan (Cilexetil) Losartan (potassium) Atosiban Mepenzolate (Bromide) NKP608 Valsartan Empty
h Empty LCZ696 Conivaptan (hydrochloride) Tranilast (trans-) K-Ras(G12C) inhibitor 12 N6-(4-Hydroxybenzyl)adenosine N6-Cyclohexyladenosine LY354740 GR79236 Orexin 2 Receptor Agonist ZM241385 Empty

Plate layout: HY-L006-4

1 2 3 4 5 6 7 8 9 10 11 12
a Empty SCH 58261 lumateperone (Tosylate) TY-52156 VU0357017 (hydrochloride) NAN-190 (hydrobromide) JNJ-63533054 Adomeglivant MK-571 (sodium salt) GSK137647A Clemizole (hydrochloride) Empty
b Empty Setiptiline Setiptiline (maleate) MK-0974 AMD-070 (hydrochloride) Laropiprant INCB3344 GW-1100 Calcium-Sensing Receptor Antagonists I Ibutamoren (Mesylate) ONO-AE3-208 Empty
c Empty LY404039 Plerixafor (octahydrochloride) Cinacalcet Cinacalcet (hydrochloride) Alosetron (Hydrochloride) SB-408124 CCG-63802 CCG-63808 Rotigotine Methylnaltrexone (Bromide) Empty
d Empty (R)-5-Hydroxymethyl Tolterodine SB-408124 (Hydrochloride) Alvimopan (dihydrate) Naltrexone (Hydrochloride) Naltrexone Cevimeline (hydrochloride hemihydrate) Cortodoxone Tianeptine Tianeptine (sodium salt) Solifenacin (Succinate) Empty
e Empty Rotigotine (Hydrochloride) B-HT 920 Darifenacin (hydrobromide) Bosentan Bosentan (hydrate) Ramelteon Bepotastine (Beslilate) Paliperidone Palonosetron (Hydrochloride) Fenspiride (Hydrochloride) Empty
f Empty Tolazoline (hydrochloride) Doxylamine (succinate) Decloxizine (dihydrochloride) Perphenazine Fluphenazine (dihydrochloride) Diphenidol (hydrochloride) Methacholine (chloride) Flibanserin Histamine (phosphate) Dapiprazole (hydrochloride) Empty
g Empty Regadenoson Amezinium (methylsulfate) Ondansetron (hydrochloride dihydrate) Ondansetron Carvedilol Formoterol (Fumarate) Tropisetron (Hydrochloride) Quetiapine (fumarate) Lurasidone (Hydrochloride) Azasetron (hydrochloride) Empty
h Empty Granisetron (Hydrochloride) (±)-Bisoprolol (hemifumarate) Doxazosin (mesylate) Pizotifen Sumatriptan (succinate) Topiramate Diphylline Prostaglandin E1 Pregnenolone Ticlopidine (hydrochloride) Empty

Plate layout: HY-L006-5

1 2 3 4 5 6 7 8 9 10 11 12
a Empty Fluticasone (propionate) Ketotifen (fumarate) Lafutidine Ivabradine (hydrochloride) Detomidine (hydrochloride) Mizolastine Azatadine (dimaleate) Mianserin (hydrochloride) Mosapride (citrate) Alfuzosin Empty
b Empty Prazosin (hydrochloride) Tizanidine (hydrochloride) Tranilast Naratriptan (hydrochloride) Irbesartan Nebivolol (hydrochloride) Candesartan Rizatriptan (benzoate) L-(-)-α-Methyldopa (hydrate) Zolmitriptan Empty
c Empty Ipratropium (bromide) Meprednisone Desonide Methylprednisolone Oxybutynin Oxybutynin (chloride) Chlorprothixene Ranitidine (hydrochloride) Acetylcholine (chloride) Chlorpheniramine (maleate) Empty
d Empty Clemastine (fumarate) Diphenhydramine (hydrochloride) Roxatidine (Acetate Hydrochloride) Nizatidine Tropicamide Sulfisoxazole Irsogladine Triamcinolone Meclizine (dihydrochloride) Mirtazapine Empty
e Empty Phentolamine (mesylate) Cyproheptadine (hydrochloride) Terazosin (hydrochloride dihydrate) Moxonidine Famotidine Trimebutine (maleate) Betaxolol Betaxolol (hydrochloride) Levobetaxolol (hydrochloride) Almotriptan (malate) Empty
f Empty Naftopidil Atropine (sulfate monohydrate) Bethanechol (chloride) Chlorpromazine (hydrochloride) Clonidine (hydrochloride) Domperidone Fluocinolone (Acetonide) Gallamine Triethiodide Loperamide (hydrochloride) Olopatadine (hydrochloride) Empty
g Empty Oxymetazoline (hydrochloride) Phenoxybenzamine (hydrochloride) Salbutamol (hemisulfate) Sotalol (hydrochloride) Xylazine (hydrochloride) Naphazoline (hydrochloride) DL-Epinephrine L-Epinephrine (Bitartrate) L-Epinephrine Dopamine (hydrochloride) Empty
h Empty Ritodrine (hydrochloride) Clomipramine (hydrochloride) Scopine (hydrochloride) Trospium (chloride) Azelastine (hydrochloride) Isoprenaline (hydrochloride) (R)-(-)-Phenylephrine (hydrochloride) Xylometazoline (hydrochloride) Trazodone (hydrochloride) Brompheniramine (maleate) Empty

Plate layout: HY-L006-6

1 2 3 4 5 6 7 8 9 10 11 12
a Empty Fluocinonide Arecoline (hydrobromide) Otilonium (bromide) Alverine (citrate) Benztropine (mesylate) Betahistine (dihydrochloride) Octopamine (hydrochloride) Trifluoperazine (dihydrochloride) Pemirolast (potassium) Desloratadine Empty
b Empty Homatropine (Bromide) Hydroxyzine (dihydrochloride) Flavoxate (hydrochloride) Tetrahydrozoline (hydrochloride) Guanabenz (Acetate) Propranolol (hydrochloride) Ramosetron (Hydrochloride) Ropinirole (hydrochloride) Ciclesonide Triamcinolone (acetonide) Empty
c Empty Epinastine UK 14,304 (tartrate) Tamsulosin Imidafenacin Ebastine Pilocarpine (Hydrochloride) Fenoldopam (mesylate) Cyclobenzaprine (hydrochloride) Dalasetron (Mesylate hydrate) Fimasartan Empty
d Empty Promethazine (hydrochloride) Fexofenadine (hydrochloride) Terbutaline (sulfate) Theophylline Suramin (sodium salt) Triflupromazine (hydrochloride) Pyrithioxin (dihydrochloride) Thioridazine (hydrochloride) Diphenylpyraline (hydrochloride) Pheniramine (Maleate) Empty
e Empty Fenoterol (hydrobromide) Molindone (hydrochloride) Sulpiride Levosulpiride Antazoline (hydrochloride) Ethamsylate Naftidrofuryl (oxalate) Labetalol (hydrochloride) Cyproheptadine (hydrochloride sesquihydrate) Histamine Empty
f Empty Carbamoylcholine (chloride) Dimenhydrinate Promazine (hydrochloride) Droperidol Trihexyphenidyl (hydrochloride) Citalopram (hydrobromide) Mebhydrolin (napadisylate) Adrenalone (hydrochloride) Homatropine (methylbromide) Esmolol (hydrochloride) Empty
g Empty Azaperone Deoxycorticosterone (acetate) Benzetimide (hydrochloride) Chlorphenoxamine Clebopride (malate) Methoxyphenamine (Hydrochloride) Levodropropizine Solifenacin (hydrochloride) Baohuoside I Ferulic acid (sodium) Empty
h Empty Synephrine (hydrochloride) Matrine Scopolamine (hydrobromide) L-DOPA L-Glutamine L-Hyoscyamine Hydrocortisone Harmine Tetrahydroberberine Tyr-Gly-Gly-Phe-Met-OH Empty

Plate layout: HY-L006-7

1 2 3 4 5 6 7 8 9 10 11 12
a Empty TRAP-6 Neuromedin N Angiotensin II 5-valine Empty Empty Empty Empty Empty Empty Empty Empty
b Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty
c Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty
d Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty
e Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty
f Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty
g Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty
h Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty Empty
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