GPCR/G Protein Compound Library

(1961 compounds) Cat. No.: HY-L006: Library Contents: XLSX PDF

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. GPCRs play an important role in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third to one-half of all approved drugs act by binding to GPCRs. GPCRs are a large group of drug targets in drug discovery.

MCE provides a unique collection of 1961 small molecules targeting GPCRs that can be used in the screening for various GPCRs-related research and drug development projects.

Size (Pre-dissolved DMSO or Solid)	Price	Stock
30 μL/well (10 mM solution)	Get quote	In-stock
50 μL/well (10 mM solution)	Get quote	In-stock
100 μL/well (10 mM solution)	Get quote	In-stock
250 μL/well (10 mM solution)	Get quote	In-stock

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Description
Product Details
Composition
Contents
Documentation

Description
& Advantages

• A unique collection of 1961 small molecules targeting G protein coupled receptors used in GPCR screening for various research and drug development projects.

• Targets such as 5-HT Receptor, Dopamine Receptor, Opioid Receptor, Adrenergic Receptors, Cannabinoid Receptor, mGluR, ETA Receptor, etc.

• The most successful class of drugable targets in the human genome and remain the most attractive family of targets.

• All of the small molecules in the GPCR library are well characterized with biological and pharmaceutical activity. Some compounds have been approved by the FDA.

• A powerful tool for discovering GPCR-based drugs that are the richest signal receptor targets for drug discovery.

• Structurally diverse, medicinally active, and cell permeable.

• Rich documentation with structure, IC₅₀, and brief introduction.

• NMR and HPLC validated to ensure the highest purity.

• All compounds are in stock and continuously updated.

Product Details

Formulation:: A collection of 1961 GPCR/G Protein related compounds supplied as pre-dissolved Solutions or Solid
Container:: 96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:: -80°C
Shipping:: Blue ice

Composition

Contents of GPCR/G Protein Compound Library

Plate layout: HY-L006-1

	1	2	3	4	5	6	7	8	9	10	11	12
a	Empty	PD 117519	NPS-2143	Taranabant	4-IBP	Ro 67-7476	TCS-OX2-29	Plerixafor	Bay 59-3074	Aprepitant	Ticagrelor	Empty
b	Empty	Zibotentan	Vorapaxar	Silodosin	NPS-2143 (hydrochloride)	SCH 527123	PD 123319 (ditrifluoroacetate)	MK-3207 (Hydrochloride)	MK-2894	SKF-82958 (hydrobromide)	TAK-875	Empty
c	Empty	JDTic (dihydrochloride)	Sarpogrelate (hydrochloride)	Ponesimod	Palosuran	MK-6892	CJ-42794	Almorexant (hydrochloride)	Otenabant	Istradefylline	SB-334867 (free base)	Empty
d	Empty	SB-674042	TCS 1102	Tozadenant	Risperidone	Asenapine (maleate)	Sitaxsentan (sodium)	Fingolimod (hydrochloride)	GSK1292263	BX471	Pitolisant (hydrochloride)	Empty
e	Empty	Ozanimod	MK-3697	IBMX	Siponimod	Atipamezole (hydrochloride)	Angiotensin (1-7)	6H05 (trifluoroacetate)	SKF 38393 (hydrochloride)	Gonadorelin (acetate)	Y16	Empty
f	Empty	Prucalopride (succinate)	ML141	EHop-016	RBC8	CASIN	BQU57	SRT3190	ADL-5859	ADX-47273	MRS 2578	Empty
g	Empty	WAY-100635 (maleate salt)	CGS 21680 (Hydrochloride)	Biperiden (Hydrochloride)	MTEP (hydrochloride)	Ambrisentan	BRL 54443	BAN ORL 24	PF-4136309	JTC-801	Ki16425	Empty
h	Empty	Org 27569	WIN 55,212-2 (Mesylate)	Montelukast (sodium)	VU0152100	SB 242084	Xanomeline (oxalate)	JNJ-7777120	SA4503 (dihydrochloride)	Rupatadine (Fumarate)	LY310762	Empty

Plate layout: HY-L006-2

	1	2	3	4	5	6	7	8	9	10	11	12
a	Empty	Betamethasone	Beclometasone dipropionate	Blonanserin	Budesonide	Clobetasol propionate	Deflazacort	Leuprolide (Acetate)	Mometasone furoate	MSX-122	Noscapine	Empty
b	Empty	LY 344864	Angiotensin II human	ICI 118,551 (hydrochloride)	Telmisartan	ZCL278	AMG 837 (calcium hydrate)	UNC0642	CCG-1423	Rimonabant (Hydrochloride)	Aclidinium (Bromide)	Empty
c	Empty	Cisapride	Prucalopride	Tegaserod (maleate)	Macitentan	Vilazodone (Hydrochloride)	Vilazodone	Cimetidine	Indacaterol (maleate)	SB 271046 (Hydrochloride)	SB-742457	Empty
d	Empty	AC-55541	Fosaprepitant (dimeglumine)	VU0361737	Bilastine	Haloperidol	Olanzapine	Quetiapine	Amisulpride	Aripiprazole	Talnetant	Empty
e	Empty	Pimavanserin	Tandospirone	TBPB	MPEP (Hydrochloride)	CPPHA	Anamorelin	Salirasib	Cariprazine (hydrochloride)	Mirabegron	Adoprazine	Empty
f	Empty	Tasimelteon	Tarafenacin (D-tartrate)	Lasmiditan (hydrochloride)	NS-304	Taprenepag	Azilsartan	Avosentan	ST-836 (hydrochloride)	Reparixin (L-lysine salt)	Prasugrel	Empty
g	Empty	Ciproxifan (maleate)	MBX-2982	Cabergoline	OC000459	Lorcaserin (Hydrochloride)	SB-269970 (hydrochloride)	VU 0357121	rac-Rotigotine (Hydrochloride)	Vortioxetine	Vortioxetine (hydrobromide)	Empty
h	Empty	RS 504393	RS 127445	BML-190	AM630	AM251	CTEP	MDA 19	WZ811	Ebrotidine	CP-809101 (hydrochloride)	Empty

Plate layout: HY-L006-3

	1	2	3	4	5	6	7	8	9	10	11	12
a	Empty	AR 231453	APD668	Piboserod	GW9508	Kobe0065	kobe2602	SB-222200	NSC 23766 (trihydrochloride)	Brexpiprazole	Eprosartan (mesylate)	Empty
b	Empty	AdipoRon	AMD 3465 (hexahydrobromide)	AM095	AM095 (free acid)	Diphenmanil (methylsulfate)	UNBS5162	Asenapine (hydrochloride)	Setipiprant	EHT 1864	Oncrasin-1	Empty
c	Empty	RU 24969	CID 16020046	SB225002	Grapiprant	TG6-10-1	BD-1047 (dihydrobromide)	Tolvaptan	Olmesartan (medoxomil)	Dexmedetomidine (hydrochloride)	Medetomidine (hydrochloride)	Empty
d	Empty	Agomelatine	Alcaftadine	Cetirizine (dihydrochloride)	Loratadine	Pramipexole (dihydrochloride)	Loteprednol Etabonate	Tiotropium (Bromide)	Octreotide (acetate)	Clozapine (N-oxide)	Desmopressin (Acetate)	Empty
e	Empty	(S)-Timolol (Maleate)	Metoclopramide	Metoclopramide (hydrochloride hydrate)	Loxapine	Loxapine (succinate)	Strontium Ranelate	Alarelin (Acetate)	Ziprasidone (hydrochloride monohydrate)	Iloperidone	Guanfacine (hydrochloride)	Empty
f	Empty	Naloxone (hydrochloride)	Tripelennamine (hydrochloride)	Salmeterol (xinafoate)	Clopidogrel (hydrogen sulfate)	Cortisone (acetate)	Prednisolone	Glycopyrrolate	Meptazinol (hydrochloride)	Zafirlukast	Carteolol (hydrochloride)	Empty
g	Empty	Acebutolol (hydrochloride)	Atenolol	Bambuterol (hydrochloride)	Metoprolol (Succinate)	Candesartan (Cilexetil)	Losartan (potassium)	Atosiban	Mepenzolate (Bromide)	NKP608	Valsartan	Empty
h	Empty	LCZ696	Conivaptan (hydrochloride)	Tranilast (trans-)	K-Ras(G12C) inhibitor 12	N6-(4-Hydroxybenzyl)adenosine	N6-Cyclohexyladenosine	LY354740	GR79236	Orexin 2 Receptor Agonist	ZM241385	Empty

Plate layout: HY-L006-4

	1	2	3	4	5	6	7	8	9	10	11	12
a	Empty	SCH 58261	lumateperone (Tosylate)	TY-52156	VU0357017 (hydrochloride)	NAN-190 (hydrobromide)	JNJ-63533054	Adomeglivant	MK-571 (sodium salt)	GSK137647A	Clemizole (hydrochloride)	Empty
b	Empty	Setiptiline	Setiptiline (maleate)	MK-0974	AMD-070 (hydrochloride)	Laropiprant	INCB3344	GW-1100	Calcium-Sensing Receptor Antagonists I	Ibutamoren (Mesylate)	ONO-AE3-208	Empty
c	Empty	LY404039	Plerixafor (octahydrochloride)	Cinacalcet	Cinacalcet (hydrochloride)	Alosetron (Hydrochloride)	SB-408124	CCG-63802	CCG-63808	Rotigotine	Methylnaltrexone (Bromide)	Empty
d	Empty	(R)-5-Hydroxymethyl Tolterodine	SB-408124 (Hydrochloride)	Alvimopan (dihydrate)	Naltrexone (Hydrochloride)	Naltrexone	Cevimeline (hydrochloride hemihydrate)	Cortodoxone	Tianeptine	Tianeptine (sodium salt)	Solifenacin (Succinate)	Empty
e	Empty	Rotigotine (Hydrochloride)	B-HT 920	Darifenacin (hydrobromide)	Bosentan	Bosentan (hydrate)	Ramelteon	Bepotastine (Beslilate)	Paliperidone	Palonosetron (Hydrochloride)	Fenspiride (Hydrochloride)	Empty
f	Empty	Tolazoline (hydrochloride)	Doxylamine (succinate)	Decloxizine (dihydrochloride)	Perphenazine	Fluphenazine (dihydrochloride)	Diphenidol (hydrochloride)	Methacholine (chloride)	Flibanserin	Histamine (phosphate)	Dapiprazole (hydrochloride)	Empty
g	Empty	Regadenoson	Amezinium (methylsulfate)	Ondansetron (hydrochloride dihydrate)	Ondansetron	Carvedilol	Formoterol (Fumarate)	Tropisetron (Hydrochloride)	Quetiapine (fumarate)	Lurasidone (Hydrochloride)	Azasetron (hydrochloride)	Empty
h	Empty	Granisetron (Hydrochloride)	(±)-Bisoprolol (hemifumarate)	Doxazosin (mesylate)	Pizotifen	Sumatriptan (succinate)	Topiramate	Diphylline	Prostaglandin E1	Pregnenolone	Ticlopidine (hydrochloride)	Empty

Plate layout: HY-L006-5

	1	2	3	4	5	6	7	8	9	10	11	12
a	Empty	Fluticasone (propionate)	Ketotifen (fumarate)	Lafutidine	Ivabradine (hydrochloride)	Detomidine (hydrochloride)	Mizolastine	Azatadine (dimaleate)	Mianserin (hydrochloride)	Mosapride (citrate)	Alfuzosin	Empty
b	Empty	Prazosin (hydrochloride)	Tizanidine (hydrochloride)	Tranilast	Naratriptan (hydrochloride)	Irbesartan	Nebivolol (hydrochloride)	Candesartan	Rizatriptan (benzoate)	L-(-)-α-Methyldopa (hydrate)	Zolmitriptan	Empty
c	Empty	Ipratropium (bromide)	Meprednisone	Desonide	Methylprednisolone	Oxybutynin	Oxybutynin (chloride)	Chlorprothixene	Ranitidine (hydrochloride)	Acetylcholine (chloride)	Chlorpheniramine (maleate)	Empty
d	Empty	Clemastine (fumarate)	Diphenhydramine (hydrochloride)	Roxatidine (Acetate Hydrochloride)	Nizatidine	Tropicamide	Sulfisoxazole	Irsogladine	Triamcinolone	Meclizine (dihydrochloride)	Mirtazapine	Empty
e	Empty	Phentolamine (mesylate)	Cyproheptadine (hydrochloride)	Terazosin (hydrochloride dihydrate)	Moxonidine	Famotidine	Trimebutine (maleate)	Betaxolol	Betaxolol (hydrochloride)	Levobetaxolol (hydrochloride)	Almotriptan (malate)	Empty
f	Empty	Naftopidil	Atropine (sulfate monohydrate)	Bethanechol (chloride)	Chlorpromazine (hydrochloride)	Clonidine (hydrochloride)	Domperidone	Fluocinolone (Acetonide)	Gallamine Triethiodide	Loperamide (hydrochloride)	Olopatadine (hydrochloride)	Empty
g	Empty	Oxymetazoline (hydrochloride)	Phenoxybenzamine (hydrochloride)	Salbutamol (hemisulfate)	Sotalol (hydrochloride)	Xylazine (hydrochloride)	Naphazoline (hydrochloride)	DL-Epinephrine	L-Epinephrine (Bitartrate)	L-Epinephrine	Dopamine (hydrochloride)	Empty
h	Empty	Ritodrine (hydrochloride)	Clomipramine (hydrochloride)	Scopine (hydrochloride)	Trospium (chloride)	Azelastine (hydrochloride)	Isoprenaline (hydrochloride)	(R)-(-)-Phenylephrine (hydrochloride)	Xylometazoline (hydrochloride)	Trazodone (hydrochloride)	Brompheniramine (maleate)	Empty

Plate layout: HY-L006-6

	1	2	3	4	5	6	7	8	9	10	11	12
a	Empty	Fluocinonide	Arecoline (hydrobromide)	Otilonium (bromide)	Alverine (citrate)	Benztropine (mesylate)	Betahistine (dihydrochloride)	Octopamine (hydrochloride)	Trifluoperazine (dihydrochloride)	Pemirolast (potassium)	Desloratadine	Empty
b	Empty	Homatropine (Bromide)	Hydroxyzine (dihydrochloride)	Flavoxate (hydrochloride)	Tetrahydrozoline (hydrochloride)	Guanabenz (Acetate)	Propranolol (hydrochloride)	Ramosetron (Hydrochloride)	Ropinirole (hydrochloride)	Ciclesonide	Triamcinolone (acetonide)	Empty
c	Empty	Epinastine	UK 14,304 (tartrate)	Tamsulosin	Imidafenacin	Ebastine	Pilocarpine (Hydrochloride)	Fenoldopam (mesylate)	Cyclobenzaprine (hydrochloride)	Dalasetron (Mesylate hydrate)	Fimasartan	Empty
d	Empty	Promethazine (hydrochloride)	Fexofenadine (hydrochloride)	Terbutaline (sulfate)	Theophylline	Suramin (sodium salt)	Triflupromazine (hydrochloride)	Pyrithioxin (dihydrochloride)	Thioridazine (hydrochloride)	Diphenylpyraline (hydrochloride)	Pheniramine (Maleate)	Empty
e	Empty	Fenoterol (hydrobromide)	Molindone (hydrochloride)	Sulpiride	Levosulpiride	Antazoline (hydrochloride)	Ethamsylate	Naftidrofuryl (oxalate)	Labetalol (hydrochloride)	Cyproheptadine (hydrochloride sesquihydrate)	Histamine	Empty
f	Empty	Carbamoylcholine (chloride)	Dimenhydrinate	Promazine (hydrochloride)	Droperidol	Trihexyphenidyl (hydrochloride)	Citalopram (hydrobromide)	Mebhydrolin (napadisylate)	Adrenalone (hydrochloride)	Homatropine (methylbromide)	Esmolol (hydrochloride)	Empty
g	Empty	Azaperone	Deoxycorticosterone (acetate)	Benzetimide (hydrochloride)	Chlorphenoxamine	Clebopride (malate)	Methoxyphenamine (Hydrochloride)	Levodropropizine	Solifenacin (hydrochloride)	Baohuoside I	Ferulic acid (sodium)	Empty
h	Empty	Synephrine (hydrochloride)	Matrine	Scopolamine (hydrobromide)	L-DOPA	L-Glutamine	L-Hyoscyamine	Hydrocortisone	Harmine	Tetrahydroberberine	Tyr-Gly-Gly-Phe-Met-OH	Empty

Plate layout: HY-L006-7

	1	2	3	4	5	6	7	8	9	10	11	12
a	Empty	TRAP-6	Neuromedin N	Angiotensin II 5-valine	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty
b	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty
c	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty
d	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty
e	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty
f	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty
g	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty
h	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty	Empty

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