2. Screening Libraries
  3. Wnt/Hedgehog/Notch Compound Library

Wnt/Hedgehog/Notch Compound Library

(382) Cat. No.: HY-L020
Library Contents: XLSX PDF

The developmental proteins Hedgehog, Notch and Wnt are key regulators of cell fate, proliferation, migration and differentiation in several tissues. Their related signaling pathways are frequently activated in tumors, and particularly in the rare subpopulation of cancer stem cells. The Wnt signaling pathway is a conserved pathway in animals. Deregulated Wnt signaling has catastrophic consequences for the developing embryo and it is now well appreciated that defective Wnt signaling is a causative factor for a number of pleiotropic human pathologies, including cancer. Hedgehog signaling pathway is linked to tumorigenesis and is aberrantly activated in a variety of cancers. The Notch signaling pathway is a highly conserved cell signaling system present in most animals. It plays an important role in cell-cell communication, and further regulates embryonic development.

MCE designs a unique collection of 382 Wnt/Hedgehog/Notch signaling pathway-related small molecules. Wnt/Hedgehog/Notch Compound Library serves as a useful tool for stem cell research and anti-cancer drug screening.

Size (Pre-dissolved DMSO or Solid) Price Stock
30 μL/well (10 mM solution) Get quote In-stock
50 μL/well (10 mM solution) Get quote In-stock
100 μL/well (10 mM solution) Get quote In-stock
250 μL/well (10 mM solution) Get quote In-stock
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  • Description

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  • Contents

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Description
& Advantages

•   A unique collection of 382 small molecule inhibitors with biological activity used for Wnt/Hedgehog/Notch pathway research and screening.

•   Targets include Notch, Gli, GSK-3, Hedgehog, Porcupine, sFRP-1, Smo, Wnt, β-catenin, etc.

•   A useful tool for the research of Wnt/Hedgehog/Notch-related regulation and diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 382 Wnt/Hedgehog/Notch signaling related compounds supplied as pre-dissolved Solutions or Solid
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice or dry ice
Composition

Contents of Wnt/Hedgehog/Notch Compound Library

Plate layout: HY-L020-1

1 2 3 4 5 6 7 8 9 10 11 12
a Empty CHIR-99021 Vismodegib AR-A014418 BIO TWS119 TDZD-8 WAY-262611 SB 216763 IWR-1 IM-12 Empty
b Empty Kenpaullone Bikinin Hexachlorophene CHIR-98014 LY2940680 GANT 58 BMS-833923 KY02111 GANT 61 IWP-2 Empty
c Empty ICG-001 Tideglusib Purmorphamine XAV-939 HhAntag SB 415286 FH535 AZD2858 IWP L6 LY2090314 Empty
d Empty PF-04449913 LDE225 (Diphosphate) LDE225 iCRT 14 WIKI4 Cyclopamine JW74 Indirubin-3'-monoxime BML-284