Allosteric Kinase Library

•   A unique collection of 4,800 carefully selected molecules via docking and visual evaluation.

•   Four type of possible allosteric kinase pockets were determined by now: 1) Myristoyl pocket; 2) Inhibitor binding mode that occupies part of binding pocket adjacent to the ATP-site; 3) PIF-pocket (regulatory site targeted); 4) pocket type I 1/2 relatively allosteric regulators of kinases (library contains 500 such compounds, only).

•   Structurally diverse.

•   No PAINS (Pan Assay Interference Compounds).

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds can be readily followed with analogues either from stock or from new syntheses.

•   Databases and compounds are provided by Enamine.

Formulation:

来源于 Enamine, 通过分子对接等精心挑选的变构激酶抑制剂。

Container:

Storage:

-80°C

Shipping:

Blue ice or dry ice