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Asinex BioDesign Library

(170,269) Cat. No.: HY-L0120V
Library Contents: XLSX PDF

“BioDesign” approach incorporates key structural features of known pharmacologically relevant natural products (e.g. alkaloids and other secondary metabolites) into synthetically feasible medicinal chemistry scaffolds. In order to identify the privileged pharmacophores, ring systems and linkers, we have carried out statistical analysis of structural features of natural products, marketed drugs, and drug candidates.

Saturated, fused ring, spiro, and bridged systems with a tendency towards multiple chiral centers are highly privileged among natural products and marketed drugs yet these structures are very poorly represented in commercial libraries. This library addressed this market need by incorporating these privileged elements into the design of novel synthetic molecules with high molecular framework diversity, multiple stereogenic centers (≥2), and degree of saturation (Fsp3 > 0.5).

Size (Pre-dissolved DMSO or Solid) Price Stock
30 μL/well (10 mM solution) Get quote In-stock
50 μL/well (10 mM solution) Get quote In-stock
100 μL/well (10 mM solution) Get quote In-stock
250 μL/well (10 mM solution) Get quote In-stock

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Description
& Advantages

•   “BioDesign” approach incorporates key structural features of known pharmacologically relevant natural products (e.g. alkaloids and other secondary metabolites) into synthetically feasible medicinal chemistry scaffolds.

•   A unique collection of 170,269 compounds with high molecular framework diversity, multiple stereogenic centers (≥2), and degree of saturation (Fsp3 > 0.5).

•   All compounds can be readily followed with analogues either from stock or from new syntheses.

•   Databases and compounds are provided by Asinex.

Product Details
Formulation:
来源于 Asinex,包含 170,269个 具备较高饱和度(av.Fsp3>0.5),多手性中心(av.≥2)和多样性的分子。该库化合物含有已知药理学相关天然产物(如生物碱和其他次生代谢物)的关键结构特征,药物分子优势骨架(如螺环、桥环、稠环等),适用于AI药物筛选,虚拟筛选等。
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-80°C
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Contents of Asinex BioDesign Library
Documentation

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Asinex BioDesign Library
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