2. Screening Libraries
  3. Chemspace CNS-Focused Library

Chemspace CNS-Focused Library

(13,082) Cat. No.: HY-L0124V
Library Contents: XLSX PDF

The basic requirements for the compounds that are supposed to penetrate the blood-brain barrier are somewhat different from those for the majority of drug discovery projects. Alongside the known problem with delivery of the large and non-polar compounds and their penetrability through the cell membrane, the other issue arises as well: small and polar compounds are not able to pass the Blood-Brain Barrier. Chemspace CNS-focused library comprises quite small, non-polar compounds that are also free from PAINS/toxic fragments and aggregators.

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Description
& Advantages

•   A unique collection of 13,082 highly CNS-like diverse molecules.

•   All compounds accord with the following physchem limitations: MW ≤ 450, SlogP ≤ 5, HBD count ≤ 4, HBA count ≤ 8, RB count ≤ 8, H-bond count ≤ 8, pKa 6.5-10.5, neutral or basic compounds, TPSA 40-100 Å2.

•   Databases and compounds are provided by Chemspace.

Product Details
Formulation:
来源于Chemspace，包含13,082个非极性且不含PAINS/有毒片段的小分子化合物，符合穿透血脑屏障的理化性质要求。
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Contents of Chemspace CNS-Focused Library
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