Natural Product-like Library

Historically, natural products (NPs) have played a key role in drug discovery, especially for cancer and infectious diseases, but also in other therapeutic areas, including cardiovascular diseases (for example, statins) and multiple sclerosis (for example, fingolimod). Approximately 40 % of the drugs approved by the FDA during the last decades were natural products, their derivatives, or synthetic mimetics related to natural products.

MCE Natural Product-like Compound Library consists of 5,000 natural product-like compounds coming from a drug-like library. Each molecule contains scaffold of natural products or has a Tanimoto similarity coefficient greater than 0.6 with natural products, and natural-likeness scoring is more than -2. What’s more, compounds in the library are drug-like and readily available for re-supply, making it a powerful tool for new drug research and development. It can be widely applied in high-throughput screening (HTS) and high-content screening (HCS).